puzzle picture
1070: 75 Residue Symmetric Dimer Design
Status: Closed

Summary

Name: 1070: 75 Residue Symmetric Dimer Design
Status: Closed
Created: 04/02/2015
Points: 100
Expired: 04/09/2015 - 23:00
Difficulty: Intermediate
Description: Design a protein dimer with C2 cyclic symmetry! This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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RankGroupScorePoints
1Anthropic Dreams13,546100
2Void Crushers13,49483
3L'Alliance Francophone13,39068
4Go Science13,30655
5Beta Folders13,25444

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Comments

bkoep's picture
User offline. Last seen 7 hours 14 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 54 residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Joined: 09/24/2012
Groups: Go Science
Final non credited

I shared with scientists (>1 day too late) a rank 3 solution @ 13.510.630 pts:

http://fold.it/portal/files/chatimg/irc_447652_1428846414.png

I suppose it's not usefull anymore but it was fun.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons