90 residues, have we generated a working 20 residue protein ?

Case number:699969-2000544
Topic:General
Opened by:Bletchley Park
Status:Open
Type:Question
Opened on:Wednesday, March 25, 2015 - 09:30
Last modified:Wednesday, March 25, 2015 - 18:09

It occurred to me today that we are trying to design 90 residue proteins, but do we have real world examples of *working* 20 residue or more designed proteins by foldit players ?

In other words, have we mastered going into earth orbit before trying to fly to the moon ?

(Wed, 03/25/2015 - 09:30  |  1 comment)


jflat06's picture
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From my understanding, it isn't actually clear that designing a 20 residue protein is easier than some of the longer proteins.

Smaller proteins certainly are evaluated faster in Foldit, and have less conformational space to work with. But they also lack the number of residues required to form some of the patterns that make for stable structures. For instance, it is harder to form a good core in shorter proteins.

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