90 residues, have we generated a working 20 residue protein ?

Case number:699969-2000544
Opened by:Bletchley Park
Opened on:Wednesday, March 25, 2015 - 09:30
Last modified:Wednesday, March 25, 2015 - 18:09

It occurred to me today that we are trying to design 90 residue proteins, but do we have real world examples of *working* 20 residue or more designed proteins by foldit players ?

In other words, have we mastered going into earth orbit before trying to fly to the moon ?

(Wed, 03/25/2015 - 09:30  |  1 comment)

jflat06's picture
User offline. Last seen 13 hours 53 min ago. Offline
Joined: 09/29/2010
Groups: Window Group

From my understanding, it isn't actually clear that designing a 20 residue protein is easier than some of the longer proteins.

Smaller proteins certainly are evaluated faster in Foldit, and have less conformational space to work with. But they also lack the number of residues required to form some of the patterns that make for stable structures. For instance, it is harder to form a good core in shorter proteins.


Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons