1054: Vancomycin Binder: Shape Complementarity
|Name:||1054: Vancomycin Binder: Shape Complementarity|
|Expired:||02/27/2015 - 06:00|
|Description:||Design a binding pocket for vancomycin! Antibiotic resistance is an increasing problem and one of the last resorts for treating inflammation is the cyclic peptide vancomycin. Hence there is a general interest to generate proteins that can bind vancomycin and upon binding generate a signal. With this technology it would be possible to test patients that have been treated with antibiotics if they still have small amounts left before they leave e.g. a hospital. The aim of this puzzle is to optimize the interaction between a protein and the small molecule vancomycin.
This puzzle also introduces the new Shape Complementarity filter. Shape complementarity is a measure of how well the ligand's surface contours match the cavity of the binding pocket, and has been shown to be a good discriminator between binders and non-binders. Use the "Show Isosurface" view option to visualize the protein surface, and increase shape complementarity to improve your score!
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