1046: Player-Solution Strand Redesign

Summary

Name:

Status:

Closed

Created:

02/04/2015

Points:

100

Expired:

02/09/2015 - 20:00

Difficulty:

Intermediate

Description:

This is a puzzle where you can redesign part of a player-designed protein. This is a monomer designed by viosca for Puzzle 1024: 75 Residue Monomer Design: Zero Cysteines. Our analysis shows that most of this protein is likely to fold, but that the first strand and loop can adopt some alternative conformations. Help us redesign this region of the protein to lock down the position of the first strand! Players may make mutations only at certain positions that contact the first strand. Players may also insert two additional residues in this region, but beware that changing the shape of the protein too much will disqualify your design!

Categories:

Design, Overall

Rank

Group

Score

Points

Anthropic Dreams

9,864

100

Go Science

9,849

Void Crushers

9,841

L'Alliance Francophone

9,835

Beta Folders

9,826

Rank

Player

Group

Score

Points

Galaxie 1 2

Anthropic Dreams

9,864

100

9,859

9,859

9,858

9,855

Rank

Player

Group

Score

Points

MurloW 84 1522

Anthropic Dreams

9,858

100

9,849

9,842

9,841

9,839

Wed, 02/04/2015 - 19:38

bkoep 84 548

Offline

Joined: 11/15/2012

Groups: None

Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

Exploration: Designs that deviate from the starting structure with RMSD > 2.0Å are invalid.

Fri, 02/06/2015 - 12:30

Timo van&n... 84 7

Offline

Joined: 09/21/2011

Groups: Void Crushers

Tip for players losing exploration filter

Try to move the protein as a whole to match the starting structure. The filter is space based, not a real RMSD.

Sun, 02/08/2015 - 06:48

brow42 84 1522

Offline

Joined: 09/19/2011

Groups: None

Exploration Filter

First thing I did was shift the first helix 1 segment. This alone brought me up to 1.90 exploration. I think the loop on one end is too short. But if I can't shift it, I don't have much room to move.