puzzle picture
1045: VipB Cryo-EM Density: Ghost Density
Status: Closed


201guygeva2311 78 1421  4,3121
202Primalsoul 78 1421 Gargleblasters4,3021
203tck1988ca 78 1421  4,2991
204Talias 78 1421  4,2971
205NGanes 78 1421  4,2921
206bgiesy 78 1421  4,2871
207AryehK 78 1421  4,2641
208Paltiel 78 1421  4,2601
209perrya 78 337  4,2581
210CaliberDied 78 1421  4,2441
211Ronin-Sensei 78 1421  4,2091
212mannre 78 1421 CHE 476 Advanced Biochemistry Laboratory University of Mount Union4,1371
213zaq1202 78 1421  4,0321
214roman madala 78 593  4,0291
215akii 78 1421  4,0231
216ktyk 78 1421  3,9931
217davidjakubec 78 1421  3,8731
218Otpk 78 1421  3,8351
219basakd 78 1421  3,7681
220EffJay 78 1421  3,6841
221guineapig 78 34  3,5731
222MadTrumpeter 78 1421  3,5541
223KarenCH 78 1421 Anthropic Dreams3,3861
224sushi810 78 1421  3,2061
225bataebi 78 1421  3,1111

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Joined: 10/30/2012
Groups: Beta Folders
without the density score the

without the density score the scripts are distorting the shape, for example the scorpion tail is getting pulled into the rest of the fold.

Batz's picture
User offline. Last seen 1 week 16 hours ago. Offline
Joined: 02/16/2012
Groups: Go Science
Hint: ED has more residues than given

The chain you can see in the electron density is longer than the given chain of amino acids. If you directly start to fit one end of the chain into the density, the residues won't fit properly.
It looks like that there are about 5-6 residues missing after residue 114 (C-terminus) and about 4 residues missing before the first residue (N-terminus).

spmm's picture
User offline. Last seen 32 weeks 2 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers

Thanks Batz I think I saved the first one I did...

Joined: 05/19/2009
Groups: Contenders
residu 114 cannot be changed from loop

There is also something odd about residu 114. It cannot be changed. It will remain a loop. Residu 1 does not have this limitation. Is this intentional or an artifact ?

gitwut's picture
User offline. Last seen 32 weeks 5 days ago. Offline
Joined: 05/18/2012
Groups: Contenders
Not a fan

Sorry, but I really dislike ED puzzles, and this one is no exception. There is always too much clutter. If it were possible to toggle sidechains on/off on the cloud it would probably be easier. This cloud is better than most of the previous EDs, but I might do as well or better working it as a denovo.

I know that seeing the sidechains can occasionally give extra clues, but when trying to determine the SS/backbone, they're more a hindrance than help.

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