puzzle picture
1037: 50 Residue Symmetric Pentamer Design
Status: Closed

Summary

Name: 1037: 50 Residue Symmetric Pentamer Design
Status: Closed
Created: 01/13/2015
Points: 100
Expired: 01/21/2015 - 18:00
Difficulty: Intermediate
Description: This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
210science04,4201
22xkcd3,5691
23Crunching Family2,9571
24DSN @ Home2,2571
25Folding Dukes01

Top Evolvers

RankPlayerGroupScorePoints
21Sissue 82 1780 11,33659
22Bruno Kestemont 3 5 Go Science11,25258
23Bletchley Park 22 19 Contenders11,10055
24mimi 82 1780 Contenders11,09053
25Anfinsen_slept_here 10 21 11,03952

Top Soloists

RankPlayerGroupScorePoints
21mottiger 82 1780 Anthropic Dreams11,12459
22crpainter 82 13  11,12258
23spvincent 33 32 Contenders11,07356
24spmm 82 1780 Void Crushers11,06255
25CheezWhiz 82 1780 11,05153


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Comments

bkoep's picture
User offline. Last seen 12 hours 47 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 20% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 35% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

spmm's picture
User offline. Last seen 44 weeks 6 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
scores seem low on this?

https://fold.it/portal/node/998143 - a recent 65 res monomer design scored 10,800 - the scoreboards are red for the top ten as well.

bkoep's picture
User offline. Last seen 12 hours 47 min ago. Offline
Joined: 11/15/2012
Groups: None
I don't think so

In general, Foldit score does increase with the number of residues in a design, but "symmetric residues" do not contribute in this case. We expect designs in this puzzle to score similarly to a 50 residue monomer, with the addition of the interface points for a single monomer subunit.

spmm's picture
User offline. Last seen 44 weeks 6 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
thanks

so multiplying by 5 was a tad simplistic, good to know

Joined: 09/24/2012
Groups: Go Science
I made statistics 1-2 years ago

I found the formula was like 8000 + net filters+ about [13-25] * monomer number of residues * symmetry

That would make a potential of about
11720 to 14720 pts for this one

11523 seems quite low indeed, but I think it's much more difficult to get higher scores with the many conditions that are present now.

(In the past, you had more freedom to find unrealistic high scoring solutions).

paviraj's picture
User offline. Last seen 4 years 42 weeks ago. Offline
Joined: 01/21/2015
Groups: None
thanks

so multiplying by 5 was a tad simplistic, good to know

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