puzzle picture
1037: 50 Residue Symmetric Pentamer Design
Status: Closed

Summary

Name: 1037: 50 Residue Symmetric Pentamer Design
Status: Closed
Created: 01/13/2015
Points: 100
Expired: 01/21/2015 - 18:00
Difficulty: Intermediate
Description: This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
11 An Art That's Smart10,72710
12Gargleblasters10,5628
13Herobrine's Army10,3646
14It's over 9000!9,9174
15Russian team9,2193

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Comments

bkoep's picture
User offline. Last seen 12 hours 39 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 20% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 35% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

spmm's picture
User offline. Last seen 44 weeks 6 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
scores seem low on this?

https://fold.it/portal/node/998143 - a recent 65 res monomer design scored 10,800 - the scoreboards are red for the top ten as well.

bkoep's picture
User offline. Last seen 12 hours 39 min ago. Offline
Joined: 11/15/2012
Groups: None
I don't think so

In general, Foldit score does increase with the number of residues in a design, but "symmetric residues" do not contribute in this case. We expect designs in this puzzle to score similarly to a 50 residue monomer, with the addition of the interface points for a single monomer subunit.

spmm's picture
User offline. Last seen 44 weeks 6 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
thanks

so multiplying by 5 was a tad simplistic, good to know

Joined: 09/24/2012
Groups: Go Science
I made statistics 1-2 years ago

I found the formula was like 8000 + net filters+ about [13-25] * monomer number of residues * symmetry

That would make a potential of about
11720 to 14720 pts for this one

11523 seems quite low indeed, but I think it's much more difficult to get higher scores with the many conditions that are present now.

(In the past, you had more freedom to find unrealistic high scoring solutions).

paviraj's picture
User offline. Last seen 4 years 42 weeks ago. Offline
Joined: 01/21/2015
Groups: None
thanks

so multiplying by 5 was a tad simplistic, good to know

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