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1037: 50 Residue Symmetric Pentamer Design
Status: Closed

Groups

RankGroupScorePoints
1Beta Folders11,524100
2Anthropic Dreams11,41583
3Go Science11,38669
4Void Crushers11,35956
5Another Hour Another Point11,34145
6solo11,27836
7L'Alliance Francophone11,21429
8Contenders11,10023
9Hun-Magyar Csapat11,01718
10SETI.Germany10,88814
11 An Art That's Smart10,72710
12Gargleblasters10,5628
13Herobrine's Army10,3646
14It's over 9000!9,9174
15Russian team9,2193
16FoldIt@Netherlands8,9632
17freefolder8,7872
18Natural Abilities8,7731
19Italiani Al Lavoro8,7371
20Repro-men7,7011
210science04,4201
22xkcd3,5691
23Crunching Family2,9571
24DSN @ Home2,2571
25Folding Dukes01


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Comments

bkoep's picture
User offline. Last seen 2 days 11 hours ago. Offline
Joined: 11/15/2012
Groups: None
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Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 20% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 35% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

spmm's picture
User offline. Last seen 23 weeks 1 day ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
scores seem low on this?

https://fold.it/portal/node/998143 - a recent 65 res monomer design scored 10,800 - the scoreboards are red for the top ten as well.

bkoep's picture
User offline. Last seen 2 days 11 hours ago. Offline
Joined: 11/15/2012
Groups: None
I don't think so

In general, Foldit score does increase with the number of residues in a design, but "symmetric residues" do not contribute in this case. We expect designs in this puzzle to score similarly to a 50 residue monomer, with the addition of the interface points for a single monomer subunit.

spmm's picture
User offline. Last seen 23 weeks 1 day ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
thanks

so multiplying by 5 was a tad simplistic, good to know

Joined: 09/24/2012
Groups: Go Science
I made statistics 1-2 years ago

I found the formula was like 8000 + net filters+ about [13-25] * monomer number of residues * symmetry

That would make a potential of about
11720 to 14720 pts for this one

11523 seems quite low indeed, but I think it's much more difficult to get higher scores with the many conditions that are present now.

(In the past, you had more freedom to find unrealistic high scoring solutions).

paviraj's picture
User offline. Last seen 4 years 21 weeks ago. Offline
Joined: 01/21/2015
Groups: None
thanks

so multiplying by 5 was a tad simplistic, good to know

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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