puzzle picture
1027: 80 Residue Symmetric Tetramer Design
Status: Closed

Summary

Name: 1027: 80 Residue Symmetric Tetramer Design
Status: Closed
Created: 12/18/2014
Points: 0
Expired: 01/05/2015 - 23:00
Difficulty: Intermediate
Description: NOTE: This puzzle has been closed and reposted as Puzzle 1027b.

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

This puzzle will be online for two and half weeks, so take the opportunity to try several different designs!
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Comments

bkoep's picture
User offline. Last seen 3 days 7 hours ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 30% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 38% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

Joined: 10/30/2012
Groups: Beta Folders
this might take 17 days to

this might take 17 days to run a full run of edrw

spvincent's picture
User offline. Last seen 18 hours 33 min ago. Offline
Joined: 12/07/2007
Groups: Contenders
Why can't you insert and

Why can't you insert and delete segments? Is this an oversight or a restriction in symmetry puzzles?

bkoep's picture
User offline. Last seen 3 days 7 hours ago. Offline
Joined: 11/15/2012
Groups: None
Feature unavailable

Unfortunately, Foldit cannot handle the insertion and deletion of residues in symmetric puzzles. This is a feature we'd like to add, but it will require a (surprisingly) substantial amount of work.

Joined: 09/21/2011
Groups: Void Crushers
Too many residues in core?

Can you please explain this filter? How it is computed and explain why it is included? See: http://fold.it/portal/files/chatimg/irc_288912_1418988127.png

bkoep's picture
User offline. Last seen 3 days 7 hours ago. Offline
Joined: 11/15/2012
Groups: None
Bug

This looks like a bug, but I think we can avert it by reposting the puzzle.

Thanks for bringing this to our attention, Timo!

Joined: 10/30/2012
Groups: Beta Folders
could you check the boundary

could you check the boundary condition between too many and too few in the complex, seems maybe a bit too sensitive. keep jumping from - 200 too few and - 400 too many

played with it for a bit and could not find a place between these 2 readings

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