puzzle picture
1024: 75 Residue Monomer Design: Zero Cysteines
Status: Closed

Groups

RankGroupScorePoints
1Anthropic Dreams10,404100
2Go Science10,32783
3Void Crushers10,29069
4Gargleblasters10,28256
5L'Alliance Francophone10,22045
6Beta Folders10,21936
7Contenders10,02029
8Another Hour Another Point9,98723
9FoldIt@Netherlands9,96518
10Hun-Magyar Csapat9,93914
11 An Art That's Smart9,75910
12Italiani Al Lavoro9,4318
13Natural Abilities8,8486
14Repro-men8,4464
15SETI.Germany8,4143
16xkcd8,4042
17Herobrine's Army8,1422
18foldeRNA8,0721
19Waverki7,6611
20Crunching Family7,5911
21LS Pro Folders7,5391
22freefolder6,6481
23Geekdo6,0561
24DSN @ Home7271
25It's over 9000!01


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Comments

bkoep's picture
User offline. Last seen 2 days 6 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

Joined: 10/30/2012
Groups: Beta Folders
any chance of modifying the

any chance of modifying the mutate function, rather than having to go back and do it by hand each time one uses it.

bkoep's picture
User offline. Last seen 2 days 6 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
On the docket

You mean, modify the mutate function so it adheres to filter rules?

Sometimes the Mutate function does make a mutation that causes a filter to fail; I agree this behavior is undesired and also inefficient. This fix is high on the to-do list, and hopefully will be added soon.

spmm's picture
User offline. Last seen 18 weeks 6 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
still penalising gly in loops

gly in the loops between sheets is getting penalised.

bkoep's picture
User offline. Last seen 2 days 6 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
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Could you share this solution with us, so I can take a closer look?

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons