Thu, 12/11/2014 - 17:00
#2
any chance of modifying the
any chance of modifying the mutate function, rather than having to go back and do it by hand each time one uses it.
Fri, 12/12/2014 - 00:29
#3
On the docket
You mean, modify the mutate function so it adheres to filter rules?
Sometimes the Mutate function does make a mutation that causes a filter to fail; I agree this behavior is undesired and also inefficient. This fix is high on the to-do list, and hopefully will be added soon.
Fri, 12/12/2014 - 15:22
#4
still penalising gly in loops
gly in the loops between sheets is getting penalised.
Sun, 12/14/2014 - 20:58
#5
Share with Scientists
Could you share this solution with us, so I can take a closer look?
Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.
Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!
Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.
Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.