1024: 75 Residue Monomer Design: Zero Cysteines

Summary

Name:

Status:

Closed

Created:

12/11/2014

Points:

100

Expired:

12/18/2014 - 23:00

Difficulty:

Intermediate

Description:

In this puzzle, we're asking players to design a protein with no cysteine residues! Remember that the SS Design filter now considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Categories:

Design, Overall

Rank

Group

Score

Points

Anthropic Dreams

10,404

100

Go Science

10,327

Void Crushers

10,290

Gargleblasters

10,282

L'Alliance Francophone

10,220

Rank

Player

Group

Score

Points

Galaxie 2 2

Anthropic Dreams

10,404

100

10,400

10,396

10,395

10,348

Rank

Player

Group

Score

Points

MurloW 78 1433

Anthropic Dreams

10,400

100

10,311

10,301

10,290

10,275

Thu, 12/11/2014 - 07:41

bkoep 78 573

Offline

Joined: 11/15/2012

Groups: None

Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

Thu, 12/11/2014 - 17:00

retiredmichael 19 4

Offline

Joined: 10/30/2012

Groups: Beta Folders

any chance of modifying the

any chance of modifying the mutate function, rather than having to go back and do it by hand each time one uses it.

Fri, 12/12/2014 - 00:29

bkoep 78 573

Offline

Joined: 11/15/2012

Groups: None

On the docket

You mean, modify the mutate function so it adheres to filter rules?

Sometimes the Mutate function does make a mutation that causes a filter to fail; I agree this behavior is undesired and also inefficient. This fix is high on the to-do list, and hopefully will be added soon.