bkoep's picture
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Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

spmm's picture
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results from design puzzles?

there have been a lot design puzzles but there don't seem to have been any successful ones.

bkoep's picture
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Slow and steady

We realize it's been a while since we've given any substantial feedback on Foldit designs! Alpha/beta proteins are very tricky to design, but we've been seeing steady incremental progress. I'd like to make a blog post soon about the types of challenges we perceive in the current design environment.

spmm's picture
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glycine in a loop is getting a penalty?

it is actually facing internally towards another hydro and is loosing points. Not 'on the surface' at all.

bkoep's picture
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Fixed

This looks like a slip up in the filter setup for this specific puzzle. Should be fixed in future puzzles.

Thanks for the feedback!

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