Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.
Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.
Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!
Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.
Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.
there have been a lot design puzzles but there don't seem to have been any successful ones.
We realize it's been a while since we've given any substantial feedback on Foldit designs! Alpha/beta proteins are very tricky to design, but we've been seeing steady incremental progress. I'd like to make a blog post soon about the types of challenges we perceive in the current design environment.
it is actually facing internally towards another hydro and is loosing points. Not 'on the surface' at all.
This looks like a slip up in the filter setup for this specific puzzle. Should be fixed in future puzzles.
Thanks for the feedback!