puzzle picture
1021: 65 Residue Monomer Design: SS Design
Status: Closed

Summary

Name: 1021: 65 Residue Monomer Design: SS Design
Status: Closed
Created: 12/02/2014
Points: 100
Expired: 12/09/2014 - 23:00
Difficulty: Intermediate
Description: In this puzzle, the SS Design filter also considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Anthropic Dreams10,123100
2Beta Folders10,08581
3Contenders10,03465
4Go Science10,00652
5Void Crushers9,99541

Top Evolvers

Top Soloists



Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 24 min 25 sec ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

spmm's picture
User offline. Last seen 11 weeks 2 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
results from design puzzles?

there have been a lot design puzzles but there don't seem to have been any successful ones.

bkoep's picture
User offline. Last seen 24 min 25 sec ago. Offline
Joined: 11/15/2012
Groups: None
Slow and steady

We realize it's been a while since we've given any substantial feedback on Foldit designs! Alpha/beta proteins are very tricky to design, but we've been seeing steady incremental progress. I'd like to make a blog post soon about the types of challenges we perceive in the current design environment.

spmm's picture
User offline. Last seen 11 weeks 2 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
glycine in a loop is getting a penalty?

it is actually facing internally towards another hydro and is loosing points. Not 'on the surface' at all.

bkoep's picture
User offline. Last seen 24 min 25 sec ago. Offline
Joined: 11/15/2012
Groups: None
Fixed

This looks like a slip up in the filter setup for this specific puzzle. Should be fixed in future puzzles.

Thanks for the feedback!

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons