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1017: 85 Residue Monomer Design: More Sheets!
Status: Closed

Summary

Name: 1017: 85 Residue Monomer Design: More Sheets!
Status: Closed
Created: 11/21/2014
Points: 100
Expired: 11/28/2014 - 23:00
Difficulty: Intermediate
Description: This puzzle uses the updated Core Existence filter, and has a slightly lower threshold for identifying "core" residues. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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1L'Alliance Francophone10,625100
2Anthropic Dreams10,55685
3Beta Folders10,42671
4Contenders10,41860
5Gargleblasters10,34949

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Comments

bkoep's picture
User offline. Last seen 2 hours 5 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets.

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

Joined: 09/24/2012
Groups: Go Science
extra sheets receive bonus

it looks like

Joined: 09/24/2012
Groups: Go Science
or a bonus for any condition met

Or may be, we receive a bonus for any condition 100 % met (enough sheets would receive 150 pts, core +160, Secundary Structure +500

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons