1010: Abeta Binder Redesign
|Name:||1010: Abeta Binder Redesign|
|Expired:||11/17/2014 - 23:00|
|Description:||Help us design a binder for the Abeta peptide, a peptide associated with Alzheimer's disease! This starting structure was partially derived from Puzzle 811 results, with two extra β-strands flanking the central β-sheet. In addition, the connectivity of secondary structure elements has been altered, with new loops in several places. This puzzle has two filters: the Residue IE Score filter monitors that all PHE, TYR, and TRP residues are scoring well, and the SS Design filter prohibits GLY in sheets and helices. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.|
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