puzzle picture
Beginner Puzzle (<150): Docking Design
Status: Closed


Name: Beginner Puzzle (<150): Docking Design
Status: Closed
Created: 01/27/2014
Points: 100
Expired: 12/18/2014 - 23:00
Difficulty: Beginner
Description: We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.


If you are new to Foldit, here are detailed instructions to get you started:

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Make sure you have followed these tutorials:
- Lonely Sheets,
- Lock and Lower,
- Rebuild,
- Structure and Rebuild,
- Movin' Along,
- Control over Clashing,
- Intro to Design,
- Swappin' Sidechains,
- Mass Mutate,
- Insertion and Deletion

before starting this puzzle.

Categories: Beginner

Top Groups

2Herobrine's Army8,92485
3Oma Gawd8,92472
4E?????! Heureka!8,90961

Top Soloists

1UCDSciEnqK 51 1376  9,134100
2Protocell 51 1376  9,131100
3Sjoerdsein 51 1376  9,102100
4avarieschi 51 1376  9,09099
5seppo50v 51 1376  9,08099

Need this puzzle? Log in to download.  


Joined: 09/02/2014
Groups: None
how do I start a new puzzle

I need better instructions on how to find the puzzles with tutorials and how to start a puzzle. I can get to the description of the puzzle but there is no start button. Do I need to download each puzzle?
I did a few but can't find the way to do it again. There is no tab for Play Online when I log on.

Joined: 04/24/2014
Groups: None

Hi there!
If you have picked play online when you logged into Foldit (the smiley face button), you are already playing online!

The next menu you should see when you log in is the "main menu".
The tutorials are in the "Intro Puzzles". Simply click on the button, then click on the tutorial you want to play.
The other puzzles are "science puzzles". Simply click on the button, click on the puzzle to highlight it, and click the smile button (Play).
To reach this menu from a puzzle you are playing, go to the "menu" tab at the bottom of your screen and pick "puzzle menu".

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons