puzzle picture
998: 80 Residue Monomer Design: SS Design
Status: Closed

Summary

Name: 998: 80 Residue Monomer Design: SS Design
Status: Closed
Created: 10/15/2014
Points: 100
Expired: 10/21/2014 - 19:00
Difficulty: Intermediate
Description: In natural proteins, different amino acids show different propensities for forming secondary structures like alpha helices and beta strands. This puzzle includes a new SS Design filter that restricts the use of GLY residues in helices and sheets. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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1Anthropic Dreams10,315100
2L'Alliance Francophone10,19881
3Void Crushers10,04165
4Beta Folders9,96152
5Contenders9,92941

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Comments

bkoep's picture
User offline. Last seen 15 hours 1 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if greater than 50% of residues form helices.

Secondary Structure Design: Penalizes GLY residues in helices and sheets.

Joined: 10/30/2012
Groups: Beta Folders
might be some issues with the

might be some issues with the core existence filter, check veteran chat

Joined: 10/30/2012
Groups: Beta Folders
imo, the gly filter is out of

imo, the gly filter is out of balance with the core existence filter

Joined: 10/30/2012
Groups: Beta Folders
ignore above

ignore above

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons