The rundown on coronavirus

You don't have to be a scientist to do science! Download and play Foldit and you can help researchers discover new antiviral drugs that might stop coronavirus! The most promising solutions will be manufactured and tested at the University of Washington Institute for Protein Design in Seattle.

Foldit is run by academic research scientists. It is free to play and not-for-profit. To get started, download Foldit and create a username!

We recommend that new players start with the Foldit Intro Puzzles.
After some practice, move on to the Science Puzzles and try out the Beginner: Coronavirus puzzle.
We also have an advanced puzzle NEW advanced puzzle where you can try to design an antiviral protein from scratch!

To meet other players, check out the Foldit Discord channels.

Note: Foldit is an interactive computer game and not a distributed computing project. If you would like to donate idle CPU cycles to science, please check out the Rosetta@Home project on BOINC.

(Wed, 03/04/2020 - 05:46  |  9 comments)

A Reminder of the Community Rules

Hello all! Hope you are enjoying this fine Tuesday. I wanted to take a brief moment to remind everyone about the Foldit Community Rules. As part of the community, everyone is expected to adhere to these rules at all times, so it is important all are aware of what is expected. Here are the highlights:

  • Keep the conversation PG-rated, since there is a wide range of ages in the community. Anything deemed offensive or obscene will not be tolerated.
(Tue, 06/20/2017 - 22:30  |  1 comment)

Newsletter July 10: Triple-Quad Helices and Borromean Rings

Hey folders! Missed the latest newsletter? Check it out on our blog here. Don't forget to sign up for the mailing list here to receive weekly updates about Foldit!

(Wed, 07/15/2020 - 21:14  |  0 comments)

Developer Preview Release Soon

Hey all,

We'll be pushing out a small update to devprev soon with the following bugfix:

Bug Fixes:
* Fixed a crash related to enabling/disabling filters (

(Tue, 07/07/2020 - 22:04  |  0 comments)

Newsletter July 3: Initial Reactions

(This post was originally sent out on July 3 to our mailing list. You can sign up for the mailing list here to receive weekly updates about Foldit, including tips and tricks and see the top-scoring solutions to the week's puzzles. Don't forget to join our Discord as well to stay in the chat even when you're not folding!)

Hey folders!

Dev Josh here with your weekly Foldit update.

( Posted by  joshmiller 95 591  |  Mon, 07/06/2020 - 18:11  |  3 comments )

Foldit Lab Report #10: Lab Results

Experimental results for 100 of your best anti-inflammatory binder designs — and the new Reaction Design tool for creating small molecule drugs. Watch our latest lab report for more.

- 100 anti-inflammatory designs have been tested
- Software update: Revamped intro and NEW Reaction Design Tool

Read more about the lab results on the blog


(Wed, 07/01/2020 - 06:10  |  2 comments)

Experiment results for anti-inflammatory designs

The first experimental results are back for Foldit coronavirus anti-inflammatory designs! These experiments tested whether Foldit player designs could bind the the IL6R target. Check out the Foldit blog for more!

(Tue, 06/30/2020 - 23:48  |  0 comments)

Hotfix incoming

Hey everyone,

We're pushing out a hotfix today to address some of the issues that players have been having with the client. This will go out to devprev immediately, and main should follow soon after. Thank you for all the bug reports!

Bug Fixes:
* Fixed an issue with the crash reporter not clearing out old crash reports on Windows.
* Fixed a crash on Reaction Design puzzles.
* Fixed a crash due to OpenGL errors. Errors may still occur, but will be output to the logfile instead of crashing.
* Reduced logfile spam.

(Thu, 06/25/2020 - 21:44  |  1 comment)

New Release!

Hey everyone,

We're pushing out an update with the following fixes and features:

* Renamed the tutorial progression to "Campaign".
* The tutorial progression now follows a branching system instead of a straight linear progression.
* Added optional Science help bubbles to the tutorial text bubbles.
* Updated UI and text bubble colors to differentiate between various types of hint bubbles.


(Wed, 06/17/2020 - 19:49  |  8 comments)

Foldit Lab Report #9: Stay home, play games

A slew of new coronavirus puzzles and a software update that should improve all of your designs. Watch our latest lab report for more.

- 100 anti-inflammatory designs have been selected for lab testing
- A new software update will help beat back BUNS

- Coronavirus: structure prediction
- Coronavirus: inflammatory
- Coronavirus: binder design

- Migi's impressive backbone H-bonds

- DNA synthesis has been hampering our laboratory testing – but we have a work-around!

(Mon, 06/01/2020 - 15:26  |  4 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons