The rundown on coronavirus

You don't have to be a scientist to do science! Download and play Foldit and you can help researchers discover new antiviral drugs that might stop coronavirus! The most promising solutions will be manufactured and tested at the University of Washington Institute for Protein Design in Seattle.

Foldit is run by academic research scientists. It is free to play and not-for-profit. To get started, download Foldit and create a username!

We recommend that new players start with the Foldit Intro Puzzles.
After some practice, move on to the Science Puzzles and try out the Beginner: Coronavirus puzzle.
We also have an advanced puzzle NEW advanced puzzle where you can try to design an antiviral protein from scratch!

To meet other players, check out the Foldit Discord channels.

Note: Foldit is an interactive computer game and not a distributed computing project. If you would like to donate idle CPU cycles to science, please check out the Rosetta@Home project on BOINC.

(Wed, 03/04/2020 - 05:46  |  9 comments)

A Reminder of the Community Rules

Hello all! Hope you are enjoying this fine Tuesday. I wanted to take a brief moment to remind everyone about the Foldit Community Rules. As part of the community, everyone is expected to adhere to these rules at all times, so it is important all are aware of what is expected. Here are the highlights:

  • Keep the conversation PG-rated, since there is a wide range of ages in the community. Anything deemed offensive or obscene will not be tolerated.
(Tue, 06/20/2017 - 22:30  |  1 comment)

Coronavirus designs queued for testing!

Check out the blog for an update on CoV binder designs that will be lab-tested at the UW Institute for Protein Design!

A new video explains how we test whether designed proteins can bind to the SARS-CoV-2 spike protein:

(Wed, 03/25/2020 - 05:48  |  3 comments)

New blog post about protein binders!

Check out the latest Foldit blog post for details about our backend analysis of CoV-binder designs!

Remember, if you want to see your username in updates, make sure you agree to our username sharing form!

(Fri, 03/20/2020 - 19:24  |  2 comments)

Special update on coronavirus puzzles

In this special update we take a look at some of the best-scoring antiviral proteins designed so far by Foldit players. We then step into the laboratory to see what testing these molecules is actually going to look like. See the blog for more details!

Check out the newest Coronavirus Binder Design: Round 3 puzzle!

(Thu, 03/12/2020 - 23:02  |  3 comments)

Join our Discord!

We've recently put up a Discord server. Join here!:

(Tue, 03/03/2020 - 23:02  |  3 comments)

Foldit Lab Report #6: Coronavirus puzzle

Check out Foldit Lab Report #6 on YouTube now!

We've got a bunch of new puzzles this month — and some exciting tools coming soon!

NEWS
• Looking at electron density in Foldit is about to get a whooole lot easier (0:31)
• With the new BUNS tool, your solutions should be better behaved in the lab (2:18)

PUZZLE UPDATES
• More poly-proline helix design (3:50)
• CRISPR/Cas transposase (4:02)

(Sun, 03/01/2020 - 17:09  |  5 comments)

New coronavirus puzzle!

The Baker Lab is trying to design proteins that could be used as antiviral agents against the 2019 coronavirus! Check out Puzzle 1805b and design a protein that can bind the coronavirus spike protein!

(Fri, 02/28/2020 - 20:37  |  2 comments)

Foldit Lab Report #5: New software dev

Check out Foldit Lab Report #5 on YouTube now!

NEWS
- This month we welcome Henry! (aka milkshake)
- Check the Foldit blog for an update on DeepMind's AlphaFold

PUZZLE UPDATES
- New poly-proline helix tools are on the way
- Introducing a CRISPR puzzle
- Ever more symmetric designs
- Can you make the next top TIM?

(Sat, 02/01/2020 - 20:31  |  5 comments)

New AlphaFold blog post!

Check out the blog for a look at AlphaFold, a new method for protein structure prediction!

(Fri, 01/31/2020 - 00:57  |  3 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons