WeFold paper on CASP11 has just been accepted!
The paper is titled: "An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12"
and just as with the first WeFold paper about CASP10, Foldit played a very large part in CASP11!
In order to publish these results, however, we must now abide by the new authorship policy that journals have now implemented requiring author names and affiliations for all authors. Previously, we had used "Foldit Players" (or Players, F.) to represent all of you.
Similar to Foldit's previous publication in Nature Communications, for this paper you will all be under the group consortium: "Foldit Players", and anyone who played a CASP11 puzzle has the option to list their complete real name (we cannot use Foldit usernames).
If you played one of the CASP11 puzzles and would like your full real name to be included in the group consortium list for this paper, please follow the directions below in the comments.
We would like to emphasize that this is completely voluntary, as we will of course also have a statement in the acknowledgements thanking all Foldit players, just not by name.( Posted by beta_helix 82 2029 | Thu, 05/24/2018 - 02:35 | 2 comments )
We're in the process of upgrading some of our server software, and we will need to take the site down to do so.
We're scheduling the downtime for 11 AM PST (6 PM GMT) on Wednesday, May 30th. Puzzles have been scheduled accordingly to avoid any issues.(Wed, 05/23/2018 - 22:27 | 0 comments)
Developer Preview Release Soon
We're about to push an update to the Developer Preview that reintroduces some of the experimental intro puzzle/UI changes from the last update. We have made a number of fixes based on your feedback from the previous test. Let us know what issues are still there!(Thu, 05/17/2018 - 19:52 | 0 comments)
Foldit's 10 Year Anniversary!
Today marks the 10-year anniversary of Foldit’s launch on May 9, 2008!
In the past decade, Foldit players have advanced protein science by accurately predicting the structure of a viral protein1, by developing an algorithm for protein modeling2, and by redesigning a protein enzyme with improved activity3. Foldit players have shown that they can refine protein models better than sophisticated computer programs4, and that they can interpret electron density maps as well as expert crystallographers5. We have high hopes for the next 10 years of Foldit, and can't wait to see what Foldit players will discover next!
Protein Design in Foldit
Most recently, Foldit players have been designing brand new proteins from scratch. The ability to design proteins is a big milestone for Foldit players, and we’re excited about the new types of problems that we can start to tackle with protein design in Foldit! This achievement has been a long time in the making—below you can review previous blog posts to follow this progress over the last four years. Play the latest design puzzle now!
Nov. 1, 2013 - First batch of Foldit player-designed proteins selected for testing
Mar. 25, 2014 - Improvements in Foldit player-designed proteins
Jun. 18, 2014 - First positive testing results for a Foldit player-designed protein
Feb. 10, 2015 - First alpha/beta Foldit designs selected for testing
Feb. 28, 2017 - Better backbones yield promising alpha/beta designs
Mar. 1, 2017 - Diverse player designs fold up in the wet lab
Apr. 15, 2017 - Protein crystallography of a Foldit player design
May 30, 2017 - X-ray diffraction of a protein crystal
A high-resolution crystal structure (cyan) aligned with the design model (green) shows that this protein folds up just as it was designed by Waya, Galaxie, and Susume. The protein backbone aligns to the design with a Cα RMSD of 1.1 Å, and the sidechains in the protein core pack just as intended.
Small Molecule Design in Foldit
We’re also excited to ramp up small-molecule design in Foldit, allowing Foldit players to create new ligands that could bind to protein targets! Play the latest small-molecule design puzzle now!
New tools allow Foldit players to build small molecules that can bind to protein targets
We'd like to thank all the Foldit players that have contributed to Foldit over the last 10 years! None of this would have been possible without you! Happy folding!
1. Khatib, F. et al. Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nat Struct Mol Biol 18, 1175–1177 (2011).
2. Khatib, F. F. et al. Algorithm discovery by protein folding game players. Proc Natl Acad Sci U S A 108, 18949–18953 (2011).
3. Eiben, C. B. et al. Increased Diels-Alderase activity through backbone remodeling guided by Foldit players. Nature Biotechnology 30, 190–192 (2012).
4. Cooper, S. et al. Predicting protein structures with a multiplayer online game. Nature 466, 756–760 (2010).
5. Horowitz, S. et al. Determining crystal structures through crowdsourcing and coursework. Nat Commun 7, 12549 (2016).
We've just released an update to the game with the following fixes and features:
* Added the Pin Tool - this allows players to have greater control over where the changes to the protein backbone are rooted. To access, go to the view options and check 'Show backbone pins' (off by default, and not shown when 'advanced gui' isn't enabled). A pin will appear over each piece of protein representing where the piece is rooted. Left click and drag to move it, right click to keep the piece from moving. You can find a quick demonstration here.
* Added additional info to Foldit's crash reporting system to better track down bugs.
* The Ideal loops gallery has been removed from the RamaMapPanel. The Rama map also now shouldn't take up processing resources when it not visible.
* Sound has been re-enabled.
* Fixed some small memory leaks.
* Improved performance for several visualizations.
* Various fixes and improvements for drug-design related tools and scoring.
Note that we have removed the experimental UI/tutorial changes. Those should be popping back up in devprev soon, pending some fixes and modifications based on your feedback.
As always, thanks to our devprev players for helping test the release!(Mon, 05/07/2018 - 17:56 | 0 comments)