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Anti-inflammatory designs queued for testing!

See the blog for an update on Foldit player designs that will be lab-tested at the UW Institute for Protein Design. We'll be testing 100 different designed proteins to see if they bind to the IL6R target, which could be useful for treating COVID-19.

(Tue, 05/12/2020 - 06:51  |  0 comments)

Foldit's 12th Birthday!

(Fri, 05/08/2020 - 22:02  |  8 comments)

New Release!

Hey everyone,

We've just pushed an update with the following fixes and changes:

General:
* Added option to the options menu: "fixed camera pivot.". If unchecked, the camera will always pivot around the center of the screen, instead of around the last thing manually focused on.

Electron Density:
* Added "radius" slider to electron density panel to view only electron density data within a ball of the given radius.
* Added option to manually enter values for threshold and radius in the electron density pane.

Filters:
* Added Score filter for Buried Unsatisfied Polar Atoms.

As always, a big thanks to our developer preview players for helping to test this release!

(Tue, 05/05/2020 - 01:22  |  2 comments)

Foldit Lab Report #8: Check the Fridge

The COVID-19 lockdown continues -- but we have new updates and new puzzles anyway. Watch our latest lab report for more!

NEWS:
• Coronavirus binder testing has been delayed (0:25)

PUZZLE UPDATES:
• Aflatoxin enzymes need re-looping (1:01)
• Coronavirus protein prediction -- can you fold them all? (1:56)
• Coronavirus spike binders -- optimize 'em (2:45)
• Can protein design create a COVID-19 treatment? (3:32)
-- Controlling the cytokine storm: https://youtu.be/S63mysyN910

LAB UPDATES:
• Always check the fridge, because it might contain CRYSTALS (3:57)

DESIGN OF THE MONTH:
• Player Bruno Kestemont created a promising anti-inflamatory protein (5:06)

(Fri, 05/01/2020 - 14:30  |  52 comments)

Video Update: Stopping the Cytokine Storm

We recently kicked off a new challenge in the fight against coronavirus: design a protein that might help keep a person's immune system under control. In this video, we are joined by Umut Ulge, MD PhD, who explains what can happen to somebody's immune system after they get sick with COVID-19.

See our previous blog post for details about our scientific analysis of Foldit solutions.

If you're new to Foldit, check out this Tutorial SPEEDRUN by S0ckrates.

(Wed, 04/15/2020 - 18:35  |  0 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons