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New Release!

Hey everyone,

We've just pushed a small update out for the client with some fixes to Drug Design and Ligand-based puzzles.

Drug Design:
* Various fixes to the drug design code, including ensuring that these tools are properly disabled on non-drug design puzzles.

As always, thanks to our devprev users for helping test this release!

(Tue, 09/19/2017 - 20:19  |  1 comment)

Developer Preview Release Soon

Hey everyone, we have a small update coming out soon with some features and fixes. Here's the full list:

Intro Puzzles:
* Added a series of intro puzzles for the Blueprint Tool and Conditions.

Drug Design:
* Various fixes to the drug design code, including ensuring that these tools are properly disabled on non-drug design puzzles.

(Wed, 09/13/2017 - 23:15  |  1 comment)

San Francisco

We are also looking for Foldit players who will be in San Francisco around mid-October. If you will be in the area and would like to find out more, please send a PM to Seth Cooper.

(Wed, 09/13/2017 - 14:20  |  0 comments)

New Category: Experimental!

Hey everyone,

We've just created a new puzzle category - the Experimental category.

We're trying out this category as a way to introduce new puzzle types that aren't necessarily fit for prime time quite yet. If a puzzle is out of devprev testing, but we're still in a state of heavy refinement, we've added the Experimental category to keep it segregated from the normal puzzles.

This is useful because, if there are issues with the puzzle, they wont affect your Overall or other category scores. It also gives credit to players who are adapting to the new rulesets the fastest!

(Fri, 09/08/2017 - 20:34  |  3 comments)

New Paper out of the Baker Lab

Recently, a group from the Baker lab published a paper in Science describing a high-throughput way to test lots of protein designs at once. That paper is now available, but only though a specific link on the Baker lab website. To view the paper, head to the Baker lab site and click on second item listed (Global analysis of protein folding using massively parallel design, synthesis, and testing).

Traditionally, if you wanted to measure a protein’s structural stability, you'd first have to purify the protein (which is expensive and time-intensive) and then run some kind of protein unfolding experiment with your purified protein sample.

The authors of this paper developed a protease assay that can approximate the stability of thousands of proteins in parallel, without having to purify and test each individual protein.

The idea is that unfolded or unstable proteins will be readily chewed up by proteases; but stable, well-folded proteins will resist protease degradation and remain intact. We can then sort out which proteins survived the proteases.

From this large dataset of protein stability, the authors were also able to make some interesting conclusions about protein design. For example, they found that ASP and GLU are especially stable in the first turn of a helix; ARG and LYS are preferred in the last turn.

This experiment was made possible by cheap, high-throughput DNA synthesis. Currently, this type of DNA synthesis is limited to short stretches of DNA that can only encode proteins of <60 residues (still too small for most Foldit-designed proteins). However, this technology is getting better all the time, so we may soon be able to apply this method to test thousands of Foldit-designed proteins!

(Fri, 09/01/2017 - 21:53  |  2 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons