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Lab Report #32: Good Rotations

Collaborators are now testing VHL ligand designs in the lab, and new software features put the focus on rotatable bonds to help us create more effective molecules.

- Lab testing VHL ligand designs
- New tools for ligand design

- KLHDC2 ligand design

- A CD47 binder design by alcor29 in Puzzle 2132. The binding interface features a balance of hydrophobics (for tight binding) and polar sidechains (for folding and BUNS satisfaction). See for yourself in the Design of the Month sandbox puzzle.

(Sun, 05/01/2022 - 13:28  |  0 comments)

Hotfix Release

Hey everyone,

We'll be releasing a hotfix to devprev soon and main later today with some fixes for Foldit Drug Design.

Bug Fixes:
* Fixed some potential crashes in Foldit Drug Design code puzzles.

(Fri, 04/22/2022 - 18:02  |  0 comments)

Office Hour!

Hey everyone! Jflat06 will be leading an Office Hour on Saturday, April 23rd at 12 PM PT (Time Zone Converter).

(Thu, 04/21/2022 - 19:17  |  0 comments)

Small Molecule Design Updates

Two new blog posts related to small molecule design.

The first blog post is an update about the recent VHL ligand design puzzles: we've analyzed the results and are now synthesizing compounds.

The second blog post introduces the new KLHDC2 puzzle series, looking to create a PROTAC binder for a different protein target. The first puzzle in the series is out now.

(Wed, 04/20/2022 - 23:03  |  0 comments)

New Release!

Hey everyone,

We've just pushed an update with some features and changes for Foldit Drug Design. You'll get the chance to use them soon!

Release Notes:

* Adding a number of improvements to Foldit Drug Design.
* New Icons for several tools to ensure there are no duplicates in use.

As always, thank you to our devprev players for helping to test the release!

(Mon, 04/18/2022 - 20:19  |  1 comment)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons