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Lab Report #23: AlphaFold in Foldit

Amazing new AI software is now at your fingertips, and you can use it to boost confidence in your own protein designs!

- A new AlphaFold tool for Foldit

- Protein binder design puzzles
- Ligand binder design puzzles
- Symmetric design puzzles

- A binder design for the TGF Receptor, by an anonymous player, makes great hydrophobic packing at the binding interface while satisfying buried polar atoms with H-bonds. See for yourself in the August Design of the Month sandbox puzzle.

Remember, if you want to see your username in updates, make sure to fill out our username sharing form!

(Sun, 08/01/2021 - 07:40  |  1 comment)

Developer Preview Release: New AlphaFold prediction tool!

Hi everyone,

We have an exciting new developer preview release - we're bringing DeepMind's revolutionary AlphaFold algorithm to Foldit players! Read our blog post for more details. Devprev users can check out the new feature in the newest devprev puzzle.

(Sat, 07/31/2021 - 23:27  |  1 comment)

New Release!

Hey everyone,

We've just released an update with some changes for Dojo Mode.

- Updates to Dojo mode

(Wed, 07/28/2021 - 18:31  |  0 comments)

Developer Preview Release Soon

Hey everyone,

We're releasing an update to the develop preview with some changes for Dojo Mode.

- Updates to Dojo mode

(Thu, 07/22/2021 - 20:27  |  1 comment)

New Release!

Hey everyone!

We've just pushed out an update with some big changes to our underlying biochemistry software, Rosetta.

Rosetta provides Foldit with algorithms that represent the state-of-the-art of protein biochemistry modeling. However, the version of Rosetta you are using is now quite a few years out of date, and we'd like to get back to the cutting edge.

This update brings us up-to-date with the latest version of Rosetta. You hopefully shouldn't actually notice any changes... yet. The benefits of this update will come down the road as we begin to take advantage of the features in this more capable version of Rosetta.

Bug Fixes:
* Fixed an issue with the undo graph causing crashes under certain settings. (note: there may be other situations where this may still happen, but we have fixed at least one scenario)

As always a big thanks to our devprev players for helping to test this release.

(Thu, 07/22/2021 - 00:01  |  0 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons