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New Puzzle Series: VHL ligand design

With the new updates to the Small Molecule Design tools, we're excited to announce a new series of puzzles using these tools to make molecules which may have use in an exciting class of potential drugs (PROTACs).

See the blog post for more information on the science behind these puzzles, and keep your eye out for the "VHL ligand design" series of puzzles within the Foldit client.

(Thu, 10/21/2021 - 01:13  |  0 comments)

New Release!

Hey everyone,

We've just pushed out an update with additions and changes to Foldit Small Molecule Design. You can read more about this exciting new mode here. Read below for a full list of the changes:

* A major overhaul and update to the Small Molecule Design tool.
* Two new tutorials demonstrating how to use Small Molecule Design.
* A new "Binding Site" option in the "View Protein" section of the View Options -- this is like Cartoon Ligand, but hides parts of the protein which are far from the ligand.
* Updates to the underlying small molecule handling code.
* Updates to the Ligand Substructure objective.

As always, a big thank you to our devprev players for helping to test this release and track down those bugs!

(Wed, 10/20/2021 - 17:36  |  1 comment)

Developer Preview Release Soon

Hey everyone,

We're about to push a big update to the developer preview soon with additions and changes to Foldit Small Molecule Design. You can read more about this exciting new mode here. Read below for a full list of the changes:

* A major overhaul and update to the Small Molecule Design tool.
* Two new tutorials demonstrating how to use Small Molecule Design.
* A new "Binding Site" option in the "View Protein" section of the View Options -- this is like Cartoon Ligand, but hides parts of the protein which are far from the ligand.
* Updates to the underlying small molecule handling code.
* Updates to the Ligand Substructure objective.

(Wed, 10/13/2021 - 01:52  |  6 comments)

New Release

Hey all,

We've just released an update to the Foldit client with the following fixes and changes:

General:
* Updated the help panel.
* Scaled opengl view for high-resolution displays.
* Added an orthographic view option.
* Added structure.IsLockedAll() Lua function.
* The Pick Sidechains tool now selects among buried rotamers.

Localization:
* Added a pseudolocalization language to allow translators to see all translatable strings.
* Update the description for Korean in localization.

Bug Fixes:
* Prevent crash on filter.GetData when no data.
* Correct output in LayerScoreFilter.
* Fixed a bug causing some translations to not appear.
* Fixed crashes related to disulfides.
* Update Electron Density Panel to only contain "Select Cloud" button while in the selection interface.

As always, a big thank you to our devprev players for helping to test this release!

(Fri, 10/08/2021 - 15:05  |  0 comments)

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(Tue, 10/05/2021 - 03:09  |  0 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons