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Foldit Lab Report #2: Symmetric Design Tips

Happy Fall! Check out Foldit Lab Report #2 on YouTube now!

NEWS
- Foldit has a new community liaison
- macOS update broke Foldit (but we fixed it)
- New opinion poll about data sharing

PUZZLE UPDATES
- IL-7R binders
- Aflatoxin enzymes
- Symmetry, symmetry, symmetry

LAB UPDATE
- New genes are on their way to the lab

DESIGN TIPS!
- bkoep shows what makes a designed interface look good

(Fri, 11/01/2019 - 02:00  |  10 comments)

Developer Preview Release Soon

Hey all,

We're about to release an update to the developer preview with some small fixes and changes.

Scripts:
* Added a function GetSymCount - Return the number of symmetry copies. 0 if there are no copies.
* The AddBetweenSegments function has changed to account for symmetric bands:
- (integer segmentIndex1, integer segmentIndex2, [integer atomIndex1], [integer atomIndex2], [integer symnr2])
- Add a band between the two segments. By default bands to the backbone. Specify an atom number from 0 to structure.GetAtomCount() to band to a different atom. (0 for the default backbone atom) Returns band number. Specify an symnr from 0 to structure.GetSymCount() to band to segmentIndex2 of a symmetric copy. Thanks to Timo for these changes!

Fixes:
* Fixed a problem with the linux version using too new of a glibc, causing it to not work on older machines.
* Fixed various threading issues that may have been causing crashes.

(Mon, 10/21/2019 - 21:39  |  8 comments)

Introducing: Foldit Lab Reports!

We're excited to introduce Foldit Lab Reports, a monthly video series with bkoep and others on the Foldit team!

The purpose of this series is to share more with Foldit players about what happens behind the scenes of Foldit. The videos are meant to provide brief, informal summaries of recent activity in Foldit and in the lab. Although they may not be as informative and detailed as some of our blog posts, we hope they will stimulate more discussion, and we encourage players to ask questions and leave comments on the website!

Check out Foldit Lab Report #1 on YouTube now!

NEWS
- The Foldit team is growing!

PUZZLE UPDATES
- Symmetric protein design with smaller interfaces
- Final rounds for IL-7R binder design

LAB UPDATES
- Promising lab results for symmetric homo-dimers
- Baker Lab scientists adapt Foldit designs for hetero-dimer project

BONUS UPDATE
- The Aflatoxin Challenge returns

(Tue, 10/01/2019 - 16:00  |  20 comments)

Aflatoxin Challenge returns!

Help us redesign an enzyme to degrade aflatoxin, a dangerous carcinogen that contaminates much of the world's food supply! After an interval of lab testing by the Siegel Lab at UC Davis, we're back with a brand new strategy for breaking down aflatoxin, and we need Foldit players' help!

Check out the blog for an update on the project, and play the latest puzzle Aflatoxin Challenge: Round 13 now!

(Mon, 09/30/2019 - 23:14  |  1 comment)

Did you play a cryo-EM puzzle last year?

We're preparing a research article about Foldit players' recent work on electron density puzzles!
As usual, participating Foldit players can opt to be included as authors on the paper.

We have emailed instructions to all players who played the following puzzles:
Puzzle 1572: https://fold.it/portal/node/2005691
Puzzle 1588: https://fold.it/portal/node/2006093
Puzzle 1598: https://fold.it/portal/node/2006204
Puzzle 1606: https://fold.it/portal/node/2006275

If you played one of these puzzles and did not receive an email from our foldit.publications gmail address, please PM beta_helix as soon as possible!

UPDATE: Final deadline for this is Tuesday October 1st!

(Sat, 09/21/2019 - 16:55  |  0 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons