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Lab Report #26: Small Molecule Design

Tackle a different kind of research challenge with new tools for designing small molecules in Foldit!

- New tools for small molecule design

- Design PROTAC small molecules

- A symmetric D2 tetramer, designed by Skippysk8s, Enzyme, and an anonymous teammate in Puzzle 2050. A fully-satisfied H-bond network helps to prevent off-target assembly. Take a look for yourself in the November Design of the Month sandbox puzzle.

(Mon, 11/01/2021 - 13:03  |  2 comments)

Office hour

Hey everyone! In case you missed it, check out the latest Office Hour here!

(Mon, 11/01/2021 - 00:43  |  0 comments)

Developer Preview Release Soon!

Hey everyone,

We're about to release an update for the developer preview with the following fixes and features:

Release Notes:
* Modified Lua function structure.IsLocked to also report whether the sidechain is locked
* Pressing left/right with a single residue selected will now cycle rotamers
* Pressing ctrl + left/right with the Residue Info panel open will now cycle which residue is shown in the info panel
* Added Lua function GetABEGOColor() which takes a residue number and returns its ABEGO color as a letter
* Added Lua function GetABEGOColorAll() which returns a table of residue numbers mapping to their ABEGO color as a letter
* Added Lua function recipe.GetInfo which returns the recipe's name and ID

Bug Fixes:
* Fixes to translation strings

(Fri, 10/29/2021 - 01:39  |  1 comment)

Hotfix Release

Hey everyone,

We're pushing out a hotfix release to both the main and developer preview update groups with a hotfix to small molecule design puzzles that should address some crashes on solution loading.

Bug Fixes:
* Fixed a crash on small molecule design solution load.

(Tue, 10/26/2021 - 20:15  |  0 comments)

Office Hour 10/23/21

Hey folks! We will be having an Office Hour on #Vet on Saturday, October 23rd at 12 PM PST (Time Zone Converter). It will be led by jflat06. Looking forward to seeing y'all there!

(Thu, 10/21/2021 - 01:50  |  0 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons