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IL-2R binders queued for testing

Following our series of IL-2R binder puzzles, we've selected 115 Foldit designs to test in the lab for binding to the IL-2R target. Read more in the Foldit blog!

(Thu, 12/16/2021 - 04:21  |  0 comments)

Developer Preview Release Soon

Hey everyone,

We've got a pile of fixes and features to follow the recent interface release. Lots of stuff for bindable hotkeys, some help and tooltip clarity changes, and some crash fixes. We're working on addressing more of your feedback, so we'll be following this up more updates in the near future.

Release Notes:
- Allow action menu keyboard shortcuts to be rebound in the "Configure Keyboard Shortcuts" General Options submenu.
- Make sure that user-set keyboard shortcuts take priority over default shortcuts for other actions.
- To avoid conflicts with the actions menu, the default "Restore Very Best" and "Restore Credit Best" keyboard shortcuts were changed to Ctrl+B and Ctrl+C, respectively. These can be rebound in the "Configure Keyboard Shortcuts" General Options submenu.
- Made the "Configure Keyboard Shortcuts" dialog resizable.
- Clean up some residual keyboard shortcuts from the old interfaces & cross talk from other shortcuts. (e.g. Alt+T no longer invokes wiggle.)
- Add keyboard shortcuts for the side buttons (Help/Undo/View/Behavior/Cookbook). So as not to conflict with actions, these are F1/Alt+U/Alt+V/Alt-B/Alt+C by default. These can be rebound in the "Configure Keyboard Shortcuts" general options submenu
- Allow keyboard shortcuts to be bound to View Presets, including user defined presets (as with Recipes, these start off unbound.)
- Fix bug where the Color/View Protein/View Sidechains list in More View Options did not update when keyboard shortcuts were used.
- Add the screenshot and AlphaFold panel buttons to the list of rebindable keyboard shortcuts
- Other assorted hotkey-related bug and usability fixes.
- Update Help Menu.
- The puzzle timer tooltip has been updated to refresh more often to give an better display of the puzzle expiration.
- Puzzle timer in the scoreboard now displays minutes.
- Time abbreviations have been added.
- Address issue causing crash-on-exit bugs.
- Made small molecule design more robust to certain causes of crashes.
- Address crashes in scoring for ligand design puzzles.
- Fix bug in HBond Objective
- Fixed bug where the title wasn't resizing properly (leaving it and the objective panel as only three dots).
- The Secondary Structure action has been re-enabled for level "Folding Pathway I". This will allow players to complete it as intended.
- Adding clarity for Advanced Options buttons "Reset Roles" and "DELETE ALL OFFLINE PROGRESS"
- HBNets now show which atoms are incurring penalties.
- Added a 'grid' visualization that shows distances in angstroms.

(Tue, 12/14/2021 - 01:32  |  5 comments)

New Release - New Interface!

Hey everyone,

We've just updated the game with a new look and a new interface! You can read more about the specifics in this blog post, or if you just want a summary of what changes to expect from the new interface, check out our small guide here.

We're very grateful for the feedback provided by our devprev players and our devs have been scouring Discord, feedbacks, and comments to make sure we hear your concerns. They've been hard at work addressing these issues, with one hotfix up already with a large batch of changes.

While this update is now officially released, we are still working on some of the more difficult issues brought up by players. New updates should be coming out soon as we continue to address new and existing constructive feedback, so let us know if you see issues or have ideas for improvements!

Release Notes:
* Switched to a new common interface and updated the look and feel of the UI.
* Updated the tutorials to use this new interface.

(Tue, 12/07/2021 - 21:24  |  0 comments)

Lab Report #27: Foldit gets a makeover

Foldit scientists from the University of Washington and Vanderbilt University discuss Foldit's new user interface.

NEWS
- A brand new user interface for Foldit puzzles

PUZZLE UPDATES
- Small molecule design for PROTAC drug development

DESIGN OF THE MONTH
- A small molecule design by an anonymous player from Puzzle 2062: VHL Ligand Design: Round 2, with an aromatic ring system backing up a key hydroxyl that makes critical H-bonds to the target. Take a look for yourself in the December Design of the Month sandbox puzzle.

(Wed, 12/01/2021 - 14:01  |  1 comment)

Newsletter November 19: Check your fold before you wreck your fold!

Hey folks! Missed the latest newsletter? Be sure to check it out here! If you want to get these earlier, sign up for our mailing list!

(Wed, 11/24/2021 - 02:00  |  0 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons