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Lab Report #35: From DNA to protein (part 2)

Join us in the lab to see how scientists make the proteins that players design in Foldit. In Part 2, we begin with bacterial cells and end with pure protein. If you missed Part 1, you can catch it here.

SPECIAL
- Purifying protein designs in the lab

DESIGN OF THE MONTH
- A CD47 binder design by LociOiling and MrZanav in Puzzle 2172. This design packs tightly against the target binding site, and has great binder metrics. See for yourself in the Design of the Month sandbox puzzle.

(Mon, 08/01/2022 - 13:24  |  4 comments)

New Release!

Hey everyone,

We've just released an update with the following fixes and changes:

Release Notes:
* Reworked the objectives panel.
* Reworked the puzzle menu.
* Added a visualization for the rest of the protein to the Trim Tool.
* Updated the icons for the trim/untrim actions.
* Trimmed solutions behave like cutpoint solutions and do not get credit until untrimmed.
* Several bug fixes for Education mode.
* Fix issue where language selection wasn't being properly saved.

As always, thank you to our devprev players for helping test this release!

(Tue, 07/26/2022 - 21:08  |  2 comments)

New blog post: Electron Density

Ever wondered where electron density maps come from? Head over to the Foldit blog to learn about the science behind electron density!

(Sat, 07/16/2022 - 06:47  |  0 comments)

~~~Office Hour~~~

Hey folks! New Office Hour happening this Friday, July 15th at 10 AM MT (4 PM GMT). It will be led by horowsah. Please feel free to bring questions about reconstruction puzzles, trim tool, and education mode/educational uses.

(Wed, 07/13/2022 - 13:05  |  3 comments)

Lab Report #34: From DNA to protein

Coming join us in the lab to see how scientists make the proteins that players designed in Foldit. It all begins with an envelope full of custom DNA.

SPECIAL
- Protein designs in the lab

DESIGN OF THE MONTH
- This sandbox puzzle features a symmetric tetramer design by spvincent in Puzzle 2159. AlphaFold predicts the monomer unit will fold with high confidence, and an H-bond network at the interface should help prevent off-target assemblies. See for yourself in the Design of the Month sandbox puzzle.

(Fri, 07/01/2022 - 13:01  |  0 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons