Puzzles Feed

Closed

Puzzle
Expired: 02/08/18 23:00:00
3 comments
Top Group: Go Science
Top Player: jeff101
Top Score: 12,391
Categories:
Note: This puzzle will crash Foldit on Linux operating systems, due to a known bug related to electron density. For this reason, the puzzle is worth 0 points, and players should not feel compelled to play this puzzle to remain competitive on the leaderboards. Nevertheless, we are quite invested in this protein, and would appreciate any help from Foldit players to build a better model into this electron density map!
Puzzle
Expired: 03/15/18 23:00:00
2 comments
Top Group: Void Crushers
Top Player: pi r squared
Top Score: 10,969
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expired: 02/07/18 18:00:00
Top Group: Beta Folders
Top Player: smilingone
Top Score: 9,960
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (without disulfides bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 02/02/18 23:00:00
1 comment
Top Group: Void Crushers
Top Player: Madde
Top Score: 9,793
Categories: Design, Overall
Like Puzzle 1473, this puzzle lacks the regular design filters, although many of the design tools have been restored (i.e. Remix, Rama Map, Blueprint Panel). Foldit has changed a great deal since we ran the first Foldit design puzzle, back in August of 2009, and the results of recent design puzzles have shown that Foldit players are now perfectly capable of designing well-folded, stable proteins. We'd like to write up a paper about these results, and it will be important to have a clear picture of what happens without those special tools and filters now used for protein design. We're asking Foldit players to forget everything you've learned about protein design! This puzzle uses only a basic Rosetta scoring function, and we do not expect top-scoring designs to be realistic. But we're very curious whether Foldit players will find the same solutions as back in 2009. What is the best-scoring structure you can come up with without the design filters?
Puzzle
Expired: 02/01/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 13,388
Categories: Electron Density, Overall, Prediction
This is another protein designed by Foldit players! We've been able to purify and crystallize this protein, which was designed by tokens in Puzzle 1313. The protein crystal diffracts x-rays to a resolution of 1.9 Å, and we've been able to derive an electron density map for the crystal. We think we have a pretty good idea of this protein's structure from the electron density, but some data analysis suggests our model could be improved. We want to know if Foldit players can build a better model into the electron density!
Puzzle
Expired: 03/08/18 23:00:00
Top Group: LTCC Winter 2018
Top Player: Psych0Active
Top Score: 8,952
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expired: 01/31/18 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,773
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small protein is a component of the major histocompatibility complex (MHC) which is essential to a functioning immune system. The starting structure is a Rosetta model. This protein contains two cysteine residues that are oxidized to form one disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 01/26/18 23:00:00
2 comments
Top Group: Contenders
Top Player: johnmitch
Top Score: 10,124
Categories: Design, Overall
This is an unusual puzzle, in that we've disabled all of the special tools and filters normally used for Foldit protein design. Foldit has changed a great deal since we ran the first Foldit design puzzle, back in August of 2009, and the results of recent design puzzles have shown that Foldit players are now perfectly capable of designing well-folded, stable proteins. We'd like to write up a paper about these results, and it will be important to have a clear picture of what happens without those special tools and filters now used for protein design. For this puzzle only, we're asking Foldit players to forget everything you've learned about protein design! This puzzle uses only a basic Rosetta scoring function, and we do not expect top-scoring designs to be realistic. But we're very curious whether Foldit players will find the same solutions as back in 2009. What is the best-scoring structure you can come up with, without the filters and design tools?
Puzzle
Expired: 01/25/18 23:00:00
Top Group: Go Science
Top Player: toshiue
Top Score: 9,274
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 03/01/18 23:00:00
Top Group: Void Crushers
Top Player: Madde
Top Score: 15,099
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons