Puzzles Feed

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Puzzle
Expired: 02/28/18 18:00:00
Top Group: Beta Folders
Top Player: smilingone
Top Score: 10,202
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to maintain the reduction potential of the cell. The starting structure is a Rosetta model. This protein contains four cysteine residues, but only two of them oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 02/23/18 23:00:00
6 comments
Top Group: Gargleblasters
Top Player: ManVsYard
Top Score: 10,903
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 90-125 residues. The starting structure has 90 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 02/22/18 23:00:00
Top Group: Beta Folders
Top Player: fiendish_ghoul
Top Score: 9,577
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 03/29/18 23:00:00
Top Group: Eastern Prehistoric Force
Top Player: amphi341441
Top Score: 9,004
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expired: 02/21/18 18:00:00
Top Group: Beta Folders
Top Player: smilingone
Top Score: 10,115
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This domain is part of a T-cell receptor that recognizes pathogens in the body; the starting structure is a Rosetta model. This protein contains two cysteine residues which oxidize to form one disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 02/16/18 23:00:00
5 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,380
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 02/15/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,426
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 03/22/18 23:00:00
Top Group: Gargleblasters
Top Player: severin333
Top Score: 9,281
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expired: 02/14/18 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,050
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This pilin protein allows the P. aeruginosa bacterium to adhere to human cells, sometimes resulting in infection. The starting structure is a Rosetta model. This protein contains two cysteine residues which oxidize to form one disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 02/09/18 23:00:00
1 comment
Top Group: Beta Folders
Top Player: matosfran
Top Score: 10,803
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. In this design puzzle, we've deactivated the Ideal Loops filter, so players have more flexibility to design their own high-scoring loops! The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons