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Puzzle
Expired: 03/27/18 23:00:00
7 comments
Top Group: Gargleblasters
Top Player: ManVsYard
Top Score: 16,021
Categories: Design, Overall, Symmetry
Note: This puzzle replaces Puzzle 1499 which was posted with a problematic filter. Players may load in solutions from Puzzle 1499.
Puzzle
Expired: 05/03/18 23:00:00
1 comment
Top Group: Hun-Magyar Csapat
Top Player: Ribo-soma
Top Score: 9,310
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expired: 03/27/18 23:00:00
1 comment
Top Group: Go Science
Top Player: rabamino12358
Top Score: 1,804
Categories:
Note: This puzzle replaces Puzzle 1499 which was posted with a problematic filter. Players may load in solutions from Puzzle 1499.
Puzzle
Expired: 03/27/18 23:00:00
15 comments
Top Group: Go Science
Top Player: caglar
Top Score: 13,956
Categories:
This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the two chains. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 03/26/18 18:00:00
Top Group: Gargleblasters
Top Player: eusair
Top Score: 10,711
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This scorpion toxin is similar to the one from Puzzle 55, and binds to voltage-gated ion channels of insects. The protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/26/18 23:00:00
Top Group: Biochemistry 315 2018
Top Player: parsnip
Top Score: 12,312
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expired: 03/21/18 23:00:00
6 comments
Top Group: Void Crushers
Top Player: Madde
Top Score: 13,263
Categories: Design, Overall
The aflatoxin puzzles are back! This puzzle is very similar to Puzzle 1440: Aflatoxin Challenge: Round 1, but parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details. Unfortunately, due to the scaffold trimming and the recent Foldit update, players will not be able to load solutions from Puzzle 1440.
Puzzle
Expired: 03/20/18 23:00:00
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 11,470
Categories: Design, Overall
This is another "primitive" style design puzzle, meaning that we've disabled most of the filters normally used for Foldit protein design. This puzzle debuts a brand new, state-of-the-art score function that has shown improved accuracy in some protein modeling benchmarks. We're curious to see if this score function also improves design accuracy in Foldit. What's the best scoring design you can come up with using the new score function?
Puzzle
Expired: 03/19/18 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,706
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This scorpion toxin binds to voltage-gated ion channels in insects, resulting in full-body paralysis. The protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 03/13/18 18:00:00
Top Group: Go Science
Top Player: toshiue
Top Score: 9,203
Categories: Overall, Prediction
This is a puzzle we first ran in August of 2016; however, an error in our data handling system meant that the player solutions from that puzzle were lost before we could back them up. The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets! If players still have solutions from the original Puzzle 1271, they may load them into this puzzle.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons