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Puzzle
Expired: 06/07/18 23:00:00
2 comments
Top Group: Hun-Magyar Csapat
Top Player: Ribo-soma
Top Score: 13,075
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expired: 05/01/18 23:00:00
1 comment
Top Group: Go Science
Top Player: isaksson
Top Score: 12,533
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 04/30/18 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,700
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein was designed by the Baker Lab in 2003, and has a topology unlike any natural protein yet discovered. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/27/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,681
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 05/31/18 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: Ribo-soma
Top Score: 10,354
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expired: 05/02/18 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 13,970
Categories: Design, Overall
Redesign the active site to bind aflatoxin! This puzzle uses the same starting structure as Round 7 of the Aflatoxin Challenge, but now players may insert up to 20 extra residues into the designable loops, at a cost of 20 points per residue. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details.
Puzzle
Expired: 04/24/18 23:00:00
2 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,965
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 04/23/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: reefyrob
Top Score: 12,707
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein binds fatty acids in intestinal cells. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 05/24/18 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: Ribo-soma
Top Score: 16,741
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expired: 04/17/18 23:00:00
8 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 33,816
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1507, which was posted with an erroneous puzzle setup. Unfortunately, players will not be able to load solutions from the original Puzzle 1507.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons