Puzzles Feed

Closed

Puzzle
Expired: 05/21/18 18:00:00
1 comment
Top Group: Void Crushers
Top Player: Neil9
Top Score: 11,804
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (with no disulfide bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 05/15/18 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 12,000
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 05/16/18 23:00:00
25 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 13,973
Categories:
Note: Due to player reports of persistent crashing, this puzzle is now worth zero points, so players may skip this puzzle without any effect on their rankings. However, if players would like to continue playing the puzzle, we will still analyze the puzzle solutions. And of course, we appreciate all of the detailed feedback about the puzzle!
Puzzle
Expired: 05/14/18 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,252
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This spinach protein is critical for photosynthesis, and participates in the electron transfer chain within the chloroplast. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/14/18 23:00:00
Top Group: :)
Top Player: MicElephant
Top Score: 9,211
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expired: 05/08/18 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,354
Categories: Design, Overall
Note: This puzzle replaces the original Puzzle 1515, which was posted with an erroneous Residue Count Filter. Players may load their saved work from the original Puzzle 1515.
Puzzle
Expired: 05/09/17 23:00:00
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expired: 05/09/18 23:00:00
Top Group: Go Science
Top Player: Hollinas
Top Score: 15,135
Categories: Electron Density, Overall, Prediction
This puzzle features a protein designed by fiendish_ghoul in Puzzle 1331! Last week, we challenged players to try to predict the structure of this protein from the sequence alone, in Puzzle 1511. We have since solved the crystal structure of this protein, and here we are providing players with the refined electron density map at a resolution of 1.54 Å. The crystal's electron density shows that this protein folds up exactly as fiendish_ghoul designed it, with RMSD of 0.9 Å among Cα atoms! Players can load in solutions from Puzzle 1511 to see how their predictions fit in the electron density map, or players can try building into the electron density from an extended chain.
Puzzle
Expired: 05/08/18 23:00:00
5 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,806
Categories:
Note: This puzzle was closed early due to an erroneous Residue Count Filter, and reposted as Puzzle 1515b. Players may load their work from this puzzle into the reposted puzzle.
Puzzle
Expired: 05/07/18 18:00:00
9 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 15,585
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is able to absorb light and use the energy to transfer chloride ions across the cell membrane. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons