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Puzzle
Expires: 09/25/18 23:59:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 18,562
Categories: Electron Density, Overall, Prediction
This is a repost of Puzzle 1572, which was unable to load solutions from the previous Puzzle 1554. Players may now load solutions from Puzzle 1554, as well as any work in the original Puzzle 1572. NOTE: If you did not manually save a solution in 1554 or 1572, you can go back to either puzzle, manually save it, and the solution should appear in your manual saves for this puzzle.
Puzzle
Expires: 09/27/18 23:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 13,804
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 09/26/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: hpaege
Top Score: 10,104
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin is found in green mamba venom, and blocks the flow of calcium ions that normally depolarize the muscle cell to induce muscle contraction. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 10/15/18 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,494
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by silent gene from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expires: 10/15/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,017
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by MicElephant from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expires: 10/15/18 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 10,910
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by fiendish_ghoul from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expires: 10/15/18 23:00:00
Top Group: Beta Folders
Top Player: pvc78
Top Score: 11,814
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by actiasluna from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expires: 10/15/18 23:00:00
Top Group: Gargleblasters
Top Player: Blipperman
Top Score: 10,065
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by robgee from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expires: 10/15/18 23:00:00
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 10,950
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by Skippysk8s from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expires: 10/15/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,242
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by ManVsYard from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons