Wiggle Power Results
We recently posted a bunch of De-novo puzzles where the "High Wiggle Power" option was disabled and hopefully the results from those puzzles will explain why we've given High Wiggle Power a time-out during CASP11.
Below are RMSD plots for De-novo Freestyle 36 puzzles 864: Low Power & 868: High Power. The green dots represent your many different Foldit predictions, and for all these RMSD plots, you want to be as close to the left as possible (an RMSD=0.0 would be a perfect match to the native).
You can see that the top-scoring Foldit solution (the lowest Rosetta energy) doesn't change much between puzzles RMSD-wise. So although the high-scoring Foldit solution for puzzle 868: High Power was 9,208 (compared to 9,098 in puzzle 864: Low Power), it is not any closer to the native.
In general (and this was the case for all the Low Power/High Power plot comparisons) although the scores were better in the High Power rounds, the models were not any more accurate. We hypothesized that this could be happening because we allowed you to load in solutions from the Low Power rounds, and therefore the High Power round was mostly "drilling" down the energy landscape of those previous models (since doing that would obviously improve the in-game score!).
This is why for 880: De-novo Freestyle 38: High Power we did not let you load in solutions from the previous Low Power round.
You can see in the plots below that this High Power round had fewer green dots, but unfortunately the results are actually much worse than the Low Power round:
On the left, 876: De-novo Freestyle 38: Low Power has a very nice plot where the top-scoring Foldit model is one of the left-most points. This is not the case on the right, where the top-scoring Foldit model from 880: De-novo Freestyle 38: High Power is much further from the native than in the Low Power round.
The exciting news, however, is that the results from the Predicted Contacts rounds have been very promising!
You can see this below for the De-novo Freestyle 37 puzzles:
On the left, the top-scoring solutions for 867: De-novo Freestyle 37: Low Power are not the left-most points on the plot (they are quite far away from the native topology) but given predicted contacts, your results on the right for 875b: De-novo Freestyle 37: Predicted Contacts look great!
So we are looking forward to the Contact-assisted CASP11 targets, and hopefully this post explains why we'll give High Wiggle Power a rest during CASP11. The CASP season is long and busy enough that we don't want to waste your time gaining Foldit points, but not getting more accurate solutions!
Lastly, Seth and I wanted to thank all of you in the DC area who stopped by when we presented Foldit (and debuted nanocrafter) at the 3rd USA Science & Engineering Festival.
Next time we promise to give everyone a little bit more advanced notice, and we'll make sure to have a camera ready from day 1. At least we managed to snap a photo with Galaxie on the last day:
Thanks for all your hard work, everybody... and keep up the great folding!( Posted by beta_helix 78 1433 | Tue, 05/13/2014 - 16:10 | 9 comments )