puzzle picture
849b: De-novo Freestyle 34: Hand-folding Round
Status: Closed

Summary

Name: 849b: De-novo Freestyle 34: Hand-folding Round
Status: Closed
Created: 02/25/2014
Points: 100
Expired: 03/04/2014 - 23:00
Difficulty: Intermediate
Description: This is a corrected repost of Puzzle 849a. We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
Categories: Hand-Folding, Overall, Prediction

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Comments

bkoep's picture
User offline. Last seen 17 hours 15 min ago. Offline
Joined: 11/15/2012
Groups: None
Here are the secondary structure predictions!

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Alanines at residues 9 and 74 are highly predicted to be part of a sheet. However, the Alanines at residues 57-59 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).

________________

If you are a new Foldit player, please make sure you have completed all these tutorials before trying this puzzle:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

alcor29's picture
User offline. Last seen 1 day 17 hours ago. Offline
Joined: 11/16/2012
make 849 reloadable to 849b.

Can you please allow us to go reload the work done on 849 to 849b? Not a good thing to waste a couple of hours just to throw it away. Thanks.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons