puzzle picture
Beginner Puzzle (<150): Streptococcal Protein
Status: Closed

Summary

Name: Beginner Puzzle (<150): Streptococcal Protein
Status: Closed
Created: 02/23/2013
Points: 100
Expired: 03/27/2013 - 16:00
Difficulty: Beginner
Description: The fold of this Streptococcal Protein is trapped in a local minimum. Although it looks good, it is incorrect. This is a short 57-residue protein for new players to try out after completing the Introductory Puzzles. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. For players with fewer than 150 global points.
Categories: Beginner

Top Groups

RankGroupScorePoints
1Russian team9,516100
2SETI.Germany9,41079
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4Anthropic Dreams9,31847
5E?????! Heureka!9,31535

Top Soloists

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1Wilm 82 2287  9,566100
2autodidacticism 82 2287  9,55899
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5perrya 82 2287  9,53796


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Comments

tamirh's picture
User offline. Last seen 4 years 49 weeks ago. Offline
Joined: 05/11/2012
START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

HINT: If you are having trouble with this puzzle, try using the "Align Guide" tool:

By right clicking on a region of the protein (not the guide) it will pull up a menu with 6 tools. The bottom right one is "Align Guide". Clicking on it will align the native guide to the region of the protein you selected.
This will help you see what sections on your protein correspond to the guide!

Working with the guide is much more user friendly when you use the advanced viewing options.
In the game click on Menu->General Options and select "Show Advanced GUI" and click Done.
Click on View, turn on 'Show Outline,' set the background color to white, and view stubs on the sidechains, view the guide, and set color relative to guide. Turn all the other view options off."

For even more info: http://foldit.wikia.com/wiki/Tlaloc%27s_Strategy#Technique_for_Matching_a_Guide

marie_s's picture
User offline. Last seen 28 weeks 5 days ago. Offline
Joined: 05/18/2008
Groups: None
Tlaloc strategy is one between many

and a very old one.

If you want to fold proteins, know that there are many way to play and this variety is the main value of Foldit :

- try all puzzles not only "beginners" one,
- fold first the ones you like the most,
- try by yourself to understand what works and what doesn't,
- make your own strategy and at least try more than one, here some other strategies to play QTTN http://foldit.wikia.com/wiki/101_-_Puzzle_Levels_and_Types,
- ask for tips in global when you think you doesn't understand something.

Make sure you have follow the tutorials :
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- quest to the native
- control over clashing
before starting the puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons