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476: Unsolved Nanog Transcription Factor
Status: Closed

Summary

Name: 476: Unsolved Nanog Transcription Factor
Status: Closed
Created: 11/04/2011
Points: 150
Expired: 11/14/2011 - 23:59
Difficulty: Intermediate
Description: Introduction of Nanog into skin cells can help convert or 'reprogram' them into a state that is more stem cell-like. Solving this protein structure will help us design drugs that can activate Nanog and its binding partners as a strategy for patient-specific tissue regeneration. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. This puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.
Categories: Overall, Prediction

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RankGroupScorePoints
1Void Crushers10,940150
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RankPlayerGroupScorePoints
1Coskun 73 1891  11,001150
2TheGUmmer 73 260 Void Crushers10,930149
3spmm 73 1891 Void Crushers10,862148
4emunch 73 1891  10,848147
5marie_s 73 1891  10,848145


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Comments

beta_helix's picture
User offline. Last seen 1 hour 32 min ago. Offline
Joined: 05/09/2008
Groups: None
Additional info in the blog: http://fold.it/portal/node/991003

You can see the Zhang Server results (where you'll find secondary structure predictions, hydrophobicity predictions, homologs used and more info) here:
http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S85502/

additional information on partial threading here:

http://fold.it/portal/node/989193#comment-9965

Please make sure to try out all 5 starting Zhang Server models, since we have no clue which one is closer to the correct native structure.

Joined: 01/17/2013
Groups: None
Thanks for this blog.

Thanks for this blog. Additional transcription Nanog factor mentioned info is very educative for me. I've great time learning through the Solving ways of this protein structure will help us to create solid structure.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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