puzzle picture
1500: Aflatoxin Challenge: Round 6 with Insertions
Status: Closed

Summary

Name: 1500: Aflatoxin Challenge: Round 6 with Insertions
Status: Closed
Created: 03/21/2018
Points: 100
Expired: 04/04/2018 - 23:00
Difficulty: Intermediate
Description: The aflatoxin puzzles are back! This puzzle is very similar to Puzzle 1455: Aflatoxin Challenge: Round 4, but parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details. Unfortunately, due to the scaffold trimming and the recent Foldit update, players will not be able to load solutions from Puzzle 1455.

Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In this puzzle, players are challenged to redesign an enzyme that could break down aflatoxin molecules. The majority of the protein is frozen, with the aflatoxin ligand fixed in a binding pocket. Surrounding the binding pocket are a number of loops that might be redesigned without affecting the folding stability of the protein. In these loops, players may manipulate the protein backbone, insert additional residues, and mutate the residue sidechains. Redesign the loops of this protein to better bind the aflatoxin ligand!

This is the sixth puzzle of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.
Categories: Overall, Prediction

Top Groups

RankGroupScorePoints
1Beta Folders13,644100
2Anthropic Dreams13,56373
3Gargleblasters13,49652
4Contenders13,38336
5Go Science13,28124

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1bertro 35 6 Beta Folders13,644100
2Galaxie 2 2 Anthropic Dreams13,56398
3Enzyme 74 103 Gargleblasters13,49295
4johnmitch 74 9  13,44793
5spvincent 40 44 Contenders13,38390


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Comments

toshiue's picture
User offline. Last seen 1 hour 43 min ago. Offline
Joined: 01/31/2016
Groups: Go Science
Anyone else unable to load any shares?

Can't load any share (1500) on any client on any machine. Is anyone else having load problems? (Posted on group and veterans but no answers.)

spvincent's picture
User offline. Last seen 1 day 15 hours ago. Offline
Joined: 12/07/2007
Groups: Contenders
It took some time but

It took some time but eventually uploaded.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons