puzzle picture
1482: Medium Monomer Design
Status: Closed

Summary

Name: 1482: Medium Monomer Design
Status: Closed
Created: 02/09/2018
Points: 100
Expired: 02/16/2018 - 23:00
Difficulty: Intermediate
Description: This puzzle challenges players to design a single-chain protein with 75-90 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 2 hours 38 min ago. Offline
Joined: 11/15/2012
Groups: None
Filters

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85 70. Players may use up to 105 90 residues in total.

NinjaGreg's picture
User offline. Last seen 2 hours 59 min ago. Offline
Joined: 05/21/2010
Groups: Go Science
Something wrong with the filters?

It shows I have 75 residues, and it says it's 5 over the limit of 70. I haven't added any so what you've said above about starting with 85 is incorrect, also.

LociOiling's picture
User offline. Last seen 5 hours 58 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
Looks like it started with 75...

I'm seeing 75 segments at the start, and was able to add up to 90. Looks like the comment in the filters was copied from another puzzle.

bkoep's picture
User offline. Last seen 2 hours 38 min ago. Offline
Joined: 11/15/2012
Groups: None
Sorry!

You're right, there are some problems with this puzzle's setup. The puzzle should probably have started with 70 residues.

Since the puzzle is still technically functional, we won't bother pulling and reposting it; I've edited the comment and puzzle description above.

To clarify: Every additional residue beyond 70 will incur a 23 point penalty, and a maximum of 90 residues are allowed.

Joined: 03/05/2015
Groups: Gargleblasters
Please check also this feedback... unplayable on my machine
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons