puzzle picture
1459: Revisiting Puzzle 142: Rosetta Decoy 6
Status: Closed

Summary

Name: 1459: Revisiting Puzzle 142: Rosetta Decoy 6
Status: Closed
Created: 12/12/2017
Points: 100
Expired: 12/19/2017 - 18:00
Difficulty: Intermediate
Description: This is a throwback puzzle to the early days of Foldit. This protein was evolved in vitro to bind testosterone; the starting structure is a model produced by Rosetta. This protein contains two cysteine residues, which oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

Sequence:
AAPTATVTPSSGLSDGTVVKVAGAGLQAGTAYWVAQWARVDTGVWAYNPADNSSVTADANGSASTSLTVRRSFEGFLFDGTRWGTVDCTTAACQVGLSDAAGNGPEGVAISF
Categories: Overall, Prediction

Top Groups

RankGroupScorePoints
1Beta Folders10,247100
2Go Science10,24677
3Marvin's bunch10,20158
4Anthropic Dreams10,18643
5Gargleblasters10,17831

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons