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1310: Revisiting Puzzle 79: Pheromone
Status: Closed

Summary

Name: 1310: Revisiting Puzzle 79: Pheromone
Status: Closed
Created: 11/29/2016
Points: 100
Expired: 12/06/2016 - 18:00
Difficulty: Intermediate
Description: This is a throwback puzzle to the early days of Foldit. This pheromone protein is secreted by the protist E. raikovi to initiate conjugation, the exchange of genetic material between two cells. This protein contains ten cysteine residues that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

Sequence:
GECEQCFSDGGDCTTCFNNGTGPCANCLAGYPAGCSNSDCTAFLSQCYGGC
Categories: Overall, Prediction

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Comments

Aubade01's picture
User offline. Last seen 4 days 3 hours ago. Offline
Joined: 10/12/2013
Groups: None
Puzzele 310 - Hairpins

I my structure, and I believe in others also, there are two hairpins between segments 15 and 20. It does not seem to me that in the native fold nature would put four right angles in a loop structure. I have seen this in many recent structures and it appears the database is overly favoring hairpins.

>>>>> Aubade01(00)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons