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| Vote | # | Title | Status | Type | Submitter | Replies | Last updated |
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| 300-0 | Shake and Wiggle | Open | Question | pjwolos | 10/15 16:01, fishercat |
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| 300-0 | Server returned nothing (no data, no headers) at end of update | Open | Question | alwen | 07/28 18:48, alwen |
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| 300-0 | Server issues | Open | Suggestion | dbuske | 04/09 09:49, tamirh |
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| 300-0 | Serious issues rebuilding helices | Open | Bug | auntdeen | 10/30 21:14, auntdeen |
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| 300-0 | Serine in beta sheets | Open | Bug | mbinfield | 07/19 18:09, BootsMcGraw |
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| 300-0 | Separate Section/Categories for Recipes Based on Type on the Website | Open | Suggestion | Djinn13 | 12/13 23:37, beta_helix |
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| 300-0 | Separate evo and solo | Open | Suggestion | spmm | 02/12 05:37, Bruno Ke... |
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| 300-0 | Selenocysteine, pyrrolysine and ambiguous amino acids | Open | Suggestion | Parclytaxel | 08/30 10:04, infjamc |
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| 300-0 | Selection Interface Quality of Life Suggestions | Open | Suggestion | DoctorSo... | 10/23 22:04, DoctorSo... |
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| 300-0 | Selecting "disable non-group chat" does not carry over to the next session | Open | Suggestion | georg137 | 12/29 20:24, georg137 |
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| 300-0 | Segment mutate sets. | Open | Suggestion | viosca | 08/24 20:48, brow42 |
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| 300-0 | Script Stops when you right click a band in selection interface. | Open | Bug | phallicies | 01/31 07:51, phallicies |
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| 300-0 | Script only puzzles | Open | Suggestion | jamiexq | 07/25 15:57, brow42 |
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| 300-0 | Scoring glitch observed with 1704 | Open | Bug | georg137 | 07/31 05:55, georg137 |
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| 300-0 | Scoring bug on puzzle 1858 | Open | Bug | grogar7 | 07/07 10:10, grogar7 |
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| 300-0 | Scoring Bug 1916b | Open | Bug | Mike Cas... | 11/15 18:21, agcohn821 |
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| 300-0 | scoreboards. | Open | Suggestion | frood66 | 03/28 13:12, frood66 |
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| 300-0 | score reporting | Open | Bug | biophantom | 09/21 08:09, inkycatz |
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| 300-0 | Score not conditional when there are conditions | Open | Bug | Close At... | 10/06 16:29, yoyo was... |
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| 300-0 | score does not update | Open | DevPrev Issue | christio... | 07/12 19:24, Hanto |
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