Puzzle Categories


Top Group: Anthropic Dreams
CASP (Critical Assessment of Techniques for Protein Structure Prediction) is a protein structure prediction competition that is held every 2 years, with labs from around the world testing out their newest state-of-the-art folding methods on unpublished structures. Puzzles in this category are based on the CASP11 competition targets. To find out more about CASP, try http://en.wikipedia.org/wiki/CASP or the CASP11 website at http://predictioncenter.org/casp11
Top Group: Anthropic Dreams
In Predicted Contacts Puzzles, we have predictions for which residues should be close together, or "in contact". These contacts are shown on the Contact Map panel. In addition to this visualization, most Contact puzzles will give you a bonus for matching the predicted contacts.
Top Group: Go Science
For small molecule design puzzles, players are tasked to design inhibitors or modulators for proteins that are of therapeutic interest. This is different from protein design in that the chemical space space that can be enumerated is estimated at 10^60. Designing small molecules involves modifying individual atoms, adding and deleting fragments, and using reaction-based design for tractable synthesis of the small molecule.
Top Group: Go Science
In this category, you'll find new types of puzzles that we're trying out. The most adaptable players will be at home here.
User login
Download links:
  Windows    OSX    Linux  
(10.12 or later)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media

Only search fold.it
Other Games: Mozak
Recommend Foldit
Top New Users

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons