Players design inhibitors or modulators for folded proteins -- no protein folding required! Create new small molecules by modifying individual atoms, adding and deleting fragments, and using reaction-based design for tractable lab testing. The number of possibilities is estimated at 10^60!


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Recent small molecule design puzzles

Puzzle Status
2207: SARS-CoV-2 helicase CACHE Challenge: Round 2 Open for the next 3 days
2204: SARS-CoV-2 helicase CACHE Challenge: Round 1 Closed since 4 days ago
2163: KLHDC2 ligand design: Round 10 Closed since 3 months ago
2160: KLHDC2 ligand design: Round 9 Closed since 3 months ago
2157: KLHDC2 ligand design: Round 8 Closed since 4 months ago