Intermediate puzzles may require all of the Foldit tools, and assume players have finished the Campaign. Intermediate puzzles usually have additional Objectives, and may require you to fold a protein from scratch.


Leaderboard: top intermediate evolvers

Recent intermediate puzzles

Puzzle Status
2207: SARS-CoV-2 helicase CACHE Challenge: Round 2 Open for the next 3 days
2205: BMPR Binder Design: Round 1 Open for the next about 24 hours
2204: SARS-CoV-2 helicase CACHE Challenge: Round 1 Closed since 4 days ago
Design of the Month: September 2022 Closed since 4 days ago
2202: Two-sided Strand Binder Design: Round 6 Closed since 6 days ago