P1939 Linker new CMS bonus uncapped

Started by John McLeod

John McLeod Lv 1

20201223-e20c1e0f15-win_x86-devprev
Main group is I believe equivalent

In new Puzzle 1939 Linker, after about 8 hours running Mutate Combo 1.4 for Layers new ContactMolecularSurface Score +3564.47 points (and Secondary Structures at -300 points). This pose has just been Shared with Scientists. Public Recipe here:
https://fold.it/portal/recipe/44581

Player ichwilldiesennamen earlier noted this in the Puzzle 1939 comments here:
https://fold.it/portal/node/2011030#comment-43832

BootsMcGraw Lv 1

Most of the top scoring solutions for 1939 were heavily saturated with tryptophans. This indicates a scoring bias towards larger AAs, which are not necessarily the best ones.

I had four tryptophans in my five-helix solution for 1939, all located on the outside of my helices (and flagged as exposed) and not interacting with any other sidechains or either of the target proteins. When I substituted more appropriate sidechains (glutamate, lysine, arginine), my score dropped hundreds of points. That didn't happen before the CMS metric was in play, further lending weight to the idea of a faulty scoring mechanism for CMS.