The last few times I've played FoldIt (Mac OS X 10.4.11) there have been some irritating refresh issues. The most noticeable of these has been that when the cursor is moved over a dark brown 'dialog box' a white square appears momentarily below the cursor; the size of the square being just a little larger than the bounding box that would enclose the cursor. I don't recall there being an update and I've tried rebooting: no change. Any ideas?
This wasn't reproducible and I haven't seen it in a long time.