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Hotfix Release

Hey everyone,

We're pushing out a hotfix release to both the main and developer preview update groups with a hotfix to small molecule design puzzles that should address some crashes on solution loading.

Bug Fixes:
* Fixed a crash on small molecule design solution load.

(Tue, 10/26/2021 - 20:15  |  0 comments)

Office Hour 10/23/21

Hey folks! We will be having an Office Hour on #Vet on Saturday, October 23rd at 12 PM PST (Time Zone Converter). It will be led by jflat06. Looking forward to seeing y'all there!

(Thu, 10/21/2021 - 01:50  |  0 comments)

New Puzzle Series: VHL ligand design

With the new updates to the Small Molecule Design tools, we're excited to announce a new series of puzzles using these tools to make molecules which may have use in an exciting class of potential drugs (PROTACs).

See the blog post for more information on the science behind these puzzles, and keep your eye out for the "VHL ligand design" series of puzzles within the Foldit client.

(Thu, 10/21/2021 - 01:13  |  0 comments)

New Release!

Hey everyone,

We've just pushed out an update with additions and changes to Foldit Small Molecule Design. You can read more about this exciting new mode here. Read below for a full list of the changes:

* A major overhaul and update to the Small Molecule Design tool.
* Two new tutorials demonstrating how to use Small Molecule Design.
* A new "Binding Site" option in the "View Protein" section of the View Options -- this is like Cartoon Ligand, but hides parts of the protein which are far from the ligand.
* Updates to the underlying small molecule handling code.
* Updates to the Ligand Substructure objective.

As always, a big thank you to our devprev players for helping to test this release and track down those bugs!

(Wed, 10/20/2021 - 17:36  |  1 comment)

Developer Preview Release Soon

Hey everyone,

We're about to push a big update to the developer preview soon with additions and changes to Foldit Small Molecule Design. You can read more about this exciting new mode here. Read below for a full list of the changes:

* A major overhaul and update to the Small Molecule Design tool.
* Two new tutorials demonstrating how to use Small Molecule Design.
* A new "Binding Site" option in the "View Protein" section of the View Options -- this is like Cartoon Ligand, but hides parts of the protein which are far from the ligand.
* Updates to the underlying small molecule handling code.
* Updates to the Ligand Substructure objective.

(Wed, 10/13/2021 - 01:52  |  6 comments)
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons