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Puzzle
Expired: 06/27/17 23:00:00
Top Group: Anthropic Dreams
Top Player: fiendish_ghoul
Top Score: 9,451
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 06/23/17 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,786
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. The Core Existence filter has been relaxed such that only 25% of residues need to be buried in the protein core. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 06/22/17 18:00:00
Top Group: Gargleblasters
Top Player: dcrwheeler
Top Score: 9,630
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is involved in the process of exocytosis, transporting proteins to the cell membrane or extracellular areas. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 07/27/17 23:00:00
Top Group: GC Sommerlejr 2017
Top Player: Fog Darts
Top Score: 8,541
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expired: 06/20/17 23:00:00
Top Group: Anthropic Dreams
Top Player: tokens
Top Score: 11,270
Categories: Overall, Predicted Contacts, Prediction
This is a follow-up puzzle for Puzzles 1369 and 1372. Here we've provided the top Rosetta prediction as the starting structure. Note that predicted contacts are still available, and can be accessed from the Main menu (Selection Interface) or in the Actions tab (Classic Interface). Players may load in manual saves from Puzzles 1369 and 1372 and use them as a starting point here.
Puzzle
Expired: 06/16/17 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,255
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 65-75 residues. The Core Existence filter has been relaxed such that only 25% of residues need to be buried in the protein core. The starting structure has 65 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 07/20/17 23:00:00
Top Group: Texas Tech Red Folders
Top Player: wuhongzei
Top Score: 8,609
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expired: 06/15/17 18:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,297
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin is produced in the intestines of the African black mamba. The protein contains ten cysteines that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/13/17 23:00:00
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 9,758
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 06/09/17 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,937
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons