PuzzlesClick here to start playing
Closed

Expired: 08/27/20 23:00:00
12 comments
12 comments
Design a binder against coronavirus! This puzzle introduces new binder metrics to measure the DDG, SASA, and Shape Complementarity of your design. Because the metrics are slow and must be run manually, they are available as optional Objectives and will not award any bonuses or penalties. To calculate these metrics, open the Objectives dropdown panel and click "Run All." Other Objectives are still in effect. This puzzle prohibits SER and THR in helices, which may make it harder to satisfy BUNS, but should help the helices to fold correctly. Remember, if your designed protein creates Buried Unsats, then it will be less likely to fold and bind to the coronavirus target. (Note that this target protein includes 8 buried unsats that players may be unable to fix.) See the blog for more details about buried unsats, and for helpful tips to make a successful protein binder! Players may not load solutions from previous puzzles.

Expired: 08/26/20 23:00:00
1 comment
1 comment
Top Group: Gargleblasters
Top Player: Skippysk8s
Top Score: 22,878
Categories: Design, Overall, Symmetry
Top Player: Skippysk8s
Top Score: 22,878
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've made a subtle change to the scoring of H-bonds that should help to improve H-bond geometry for SER, THR, and TYR sidechains. We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Expired: 08/21/20 18:00:00
Top Group: Go Science
Top Player: ichwilldiesennamen
Top Score: 12,515
Categories: Overall, Prediction
Top Player: ichwilldiesennamen
Top Score: 12,515
Categories: Overall, Prediction
CASP14 has released this refinement target with starting model's GDT_HA=70. This means that about 70% of the starting structure matches the native structure. Look for better scoring folds to find the true native structure!

Expired: 08/20/20 23:00:00
2 comments
2 comments
Design an anti-inflammatory protein for COVID-19! We'd like players to keep focusing on making closely-packed interfaces with no extra Buried Unsats. This puzzle prohibits SER and THR in helices, which may make it harder to satisfy BUNS, but should help the helices to fold correctly. Remember, if your designed protein creates Buried Unsats, then it will be less likely to fold and bind to the target. (Note that this target protein includes 15 buried unsats that players may be unable to fix.) See the blog for more details about buried unsats, and for helpful tips to make a successful protein binder! Players will be unable to load solutions from previous puzzles.

Expired: 08/19/20 23:00:00
1 comment
1 comment
Top Group: Contenders
Top Player: CharlieFortsCon...
Top Score: 20,305
Categories: Design, Overall, Symmetry
Top Player: CharlieFortsCon...
Top Score: 20,305
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've made a subtle change to the scoring of H-bonds that should help to improve H-bond geometry for SER, THR, and TYR sidechains. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Expired: 08/14/20 23:00:00
CASP14 has released this refinement target with starting model's GDT_HA=59. This means that about half of the starting structure matches the native structure. Look for better scoring folds to find the true native structure!

Expired: 08/13/20 23:00:00
2 comments
2 comments
Design a binder against coronavirus! We'd like players to keep focusing on making closely packed interfaces with no extra BUNS. This puzzle prohibits SER and THR in helices, which may make it harder to satisfy BUNS, but should help the helices to fold correctly. Remember, if your designed protein creates Buried Unsats, then it will be less likely to fold and bind to the coronavirus target. (Note that this target protein includes 8 buried unsats that players may be unable to fix.) See the blog for more details about buried unsats, and for helpful tips to make a successful protein binder! Players may not load solutions from previous puzzles.

Expired: 08/12/20 23:00:00
3 comments
3 comments
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle has no H-Bond Network objective, but there is "Core Limit: Complex" objective meant to limit the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. See the puzzle comments for more Objective details.

Expired: 09/01/20 00:00:00
2 comments
2 comments
This sandbox puzzle features a symmetric trimer design by NinjaGreg, from Puzzle 1864. Note the minimal interface between symmetric chains, with excellent hydrophobic packing and zero BUNS. For more, check out Foldit Lab Report #11 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

Expired: 08/07/20 18:00:00
THIS IS A MULTISTART PUZZLE - Click "RESET PUZZLE" to cycle through both starting structures. CASP14 has released another refinement target with 2 different starting structures. They did not reveal the accuracy of either starting model, but we do know that they are both incorrect. Try to explore far enough away from both starting structures, as the highest-scoring folds might be far away from both starts!