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Puzzle
Expired: 07/13/17 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: O Seki To
Top Score: 9,026
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is found in cold water fishes; it binds and prevents the growth of ice crystals. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/17/17 23:00:00
Top Group: GC Sommerlejr 2017
Top Player: Fog Darts
Top Score: 10,932
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expired: 07/11/17 23:00:00
Top Group: Go Science
Top Player: Hollinas
Top Score: 9,350
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 07/07/17 23:00:00
2 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,050
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 95-120 residues. The Core Existence filter has been relaxed such that only 25% of residues need to be buried in the protein core. The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 07/06/17 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,469
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This domain is a component of many proteins involved in cell signaling. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/10/17 23:00:00
Top Group: MU CLA BMB 465.3W1
Top Player: weby007
Top Score: 8,951
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expired: 07/04/17 23:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 9,283
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 06/30/17 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,540
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. The Core Existence filter has been relaxed such that only 25% of residues need to be buried in the protein core. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 06/29/17 18:00:00
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 8,848
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small protein participates in electron transfer reactions in the cell. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/03/17 23:00:00
Top Group: Go Science
Top Player: Squirrely
Top Score: 14,441
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons