Closed

Note: This puzzle replaces Puzzle 1918, which had some scoring problems. Unfortunately, players may not load solutions from the original Puzzle 1918.

Note: This puzzle was closed early due to some scoring problems, and has been reposted as Puzzle 1918b. Players may not load solutions into the reposted puzzle.

Note: This puzzle replaces Puzzle 1916, which revealed a bug in the Contact Surface metric. This puzzle lacks the Contact Surface metric, but players may load solutions from the original Puzzle 1916.

Note: This puzzle was closed early due to a bug in the Contact Surface metric, and is reposted as Puzzle 1916b. Players may load solutions from this puzzle into the reposted version.

This is a throwback puzzle to the early days of Foldit. This protein was evolved in vitro to bind testosterone; the starting structure is a model produced by Rosetta. This protein contains two cysteine residues, which oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.

This is the second puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned. We have also included the parts of the actual spike that are within 20 angstroms of the termini of the helices on the binders, so you know what regions your binder has to avoid to prevent clashing. The designable helices are a possible starting point for your linker designs.

This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. This protein contains two cysteine residues, which oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

Design a binder for the viral spike of MERS-CoV! This puzzle is similar to Puzzle 1910, except that the Foldit Metrics will award increasing bonuses as you improve the DDG, SASA, and SC of your solution. The Metrics are slow to compute and run in the background, so gameplay may be different from regular puzzles. See the blog for more info about Foldit Metrics.

Note: This puzzle replaces Puzzle 1912 which was posted with an erroneous BUNS Objective. Players may not load solutions from the original Puzzle 1912.

Note: Due to an error with the BUNS Objective, this puzzle was closed early and reposted as Puzzle 1912b.