Puzzles Feed

Closed

Puzzle
Expired: 04/22/19 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 13,420
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 57 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 04/19/19 23:00:00
Top Group: Anthropic Dreams
Top Player: fiendish_ghoul
Top Score: 10,647
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 04/16/19 18:00:00
2 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,000
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This domain is a component of many proteins involved in cell signaling. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/15/19 23:00:00
7 comments
Top Group: Hold My Beer
Top Player: Steven Pletsch
Top Score: 19,250
Categories: Design, Overall
Help design a protein binder for cancer therapy!
Puzzle
Expired: 04/15/14 23:00:00
Top Group: Go Science
Top Player: NinjaGreg
Top Score: 14,553
Categories:
Help design a protein binder for cancer therapy!
Puzzle
Expired: 04/12/19 23:00:00
2 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 23,012
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 04/09/19 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,650
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 04/08/19 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,767
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small protein participates in electron transfer reactions in the cell. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/04/19 23:00:00
8 comments
Top Group: Contenders
Top Player: johnmitch
Top Score: 20,609
Categories: Design, Overall, Symmetry
Note: This puzzle replaces Puzzle 1655, which was posted with a faulty Objective. Players may load in solutions from the original Puzzle 1655.
Puzzle
Expired: 04/04/19 23:00:00
1 comment
Top Group: Russian team
Top Player: cbwest
Top Score: 17,676
Categories:
Note: This puzzle was closed early due to a faulty Objective, and reposted as Puzzle 1655b. Players may load their current work into the reposted puzzle.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons