Closed

The CASP organizers have told us that this "protein is known to form very stable homo-trimers", so we are giving you the 5 RosettaServer models for R0026 with symmetry. Resetting the puzzle will cycle through the 5 different server predictions (as well as an extended conformation). More details about this CASP target are in the puzzle comments.

This repost fixes the crashing bug with segment 2 being mutated to GLY. You can load your saved solutions from the previous puzzle to this one. In this puzzle, you're creating another hydrogen-producing catalyst similar to the one from Puzzle 644. This tiny hydrogen-producing machine is attached to two symmetric protein copies. For the first round of this puzzle, just go for high scores and have fun! More details are listed in the puzzle comments.

This puzzle has been deprecated. Please reload your solutions in "675: Hydrogen-producing Catalyst Dimer (Fixed)"

The next CASP ROLL target is another tough one. We are again providing you with 3 templates for now, and will give you some server predictions once they are released. Feel free to just work off the starting extended chain if you don't trust the alignments. More details about this CASP target are in the puzzle comments. Due to the size, we're giving you a few extra days to work on this one.

CASP ROLL is back! This latest target is particularly difficult, as we have very low confidence in the templates (you will too once you see them!). We are providing you with 3 templates for now, and will give you some server predictions once they are released. Feel free to just work off the starting extended chain if you don't trust the alignments. More details about this CASP target are in the puzzle comments.

This puzzle starts out asymmetric but needs to be made symmetric. You can move one half of it to make it match the other half, and fit them together!

We would like to welcome all the new Foldit players that have recently joined us. This puzzle is for you to try out once you've completed the Introductory Puzzles. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Good luck and welcome to Foldit! For players with fewer than 150 global points.

We would like to welcome all the new Foldit players that have recently joined us. This puzzle is for you to try out once you've completed the Introductory Puzzles. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Good luck and welcome to Foldit! For players with fewer than 15 global points.

This puzzle is designed for veteran Foldit players to help new players, and since it was up recently this version of the puzzle is only worth 10 global points.

We are giving you another currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.